98026-88-1

Basic information

• Product Name: 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE
• Synonyms: 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE;5-PyriMidinesulfonyl chloride, 2-chloro-;2-chloro-5-pyrimidinesulfonyl chloride;2-Chloro-pyrimidine-5-sulphonylchloride
• CAS NO: 98026-88-1
• Molecular Formula: C₄H₂Cl₂N₂O₂S
• Molecular Weight: 213.04
• Mol File: 98026-88-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 383.2±15.0 °C(Predicted)
• Appearance: White to cream/Crystalline Powder or Powder
• Density: 1.711±0.06 g/cm3(Predicted)
• PKA: -5.59±0.22(Predicted)
• CAS DataBase Reference: 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE(98026-88-1)
• EPA Substance Registry System: 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE(98026-88-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 98026-88-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-pyrimidine-5-sulfonyl chloride is a chemical compound with the molecular formula C5H3ClN2O2S. It is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE is a versatile building block for the preparation of various heterocyclic compounds and is commonly used in the pharmaceutical industry. It is a white to light yellow solid with a melting point of 40-42°C and a molecular weight of 192.61 g/mol. 2-Chloro-pyrimidine-5-sulfonyl chloride is a potentially hazardous material and should be handled with care, as it is corrosive and may cause skin and eye irritation upon contact.

Upstream product

• 40828-51-1 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid 
• 40828-51-1 2-hydroxy-5-pyrimidinesulfonic acid 
• 39687-77-9 2-amino-5-pyrimidinesulfonic acid 

Downstream Products

• 881675-14-5 ethyl 1-[(2-chloro-5-pyrimidine)sulfonyl]-5-phenyl-1H-pyrrole-3-carboxylate 
• 881676-98-8 1-(2-chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

Proton pump inhibitors

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R 1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R 2 , R 3 and R 4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R 5 and R 6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

PROTON PUMP INHIBITORS

Proton pump inhibitors which have excellent proton pumping activity and which can be converted in vivo into proton pump inhibitors to exhibit antiulcer effect and so on, containing compounds represented by the general formula (I) or salts thereof or prodrugs of the same: (I) wherein X and Y are each independently a free valency or a spacer whose main chain has 1 to 20 carbon atoms; R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; R2, R3 and R4 are each independently hydrogen, an optionally substituted hydrocarbon group, optionally substituted thienyl, optionally substituted benzo[b]thienyl, optionally substituted furyl, optionally substituted pyridyl, optionally substituted pyrazolyl, optionally substituted pyrimidinyl, acyl, halogeno, cyano, or nitro; and R5 and R6 are each independently hydrogen or an optionally substituted hydrocarbon group.