98044-44-1Relevant academic research and scientific papers
Bishydrazide glycoconjugates for lectin recognition and capture of bacterial pathogens
Adak, Avijit Kumar,Leonov, Alexei P.,Ding, Ning,Thundimadathil, Jyothi,Kularatne, Sumith,Low, Philip S.,Wei, Alexander
experimental part, p. 2065 - 2075 (2011/07/09)
Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The α,ω- bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 103 cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.
A STEREOCONTROLLED TOTAL SYNTHESIS OF A GANGLIO-GANGLIOSIDE GM1b, IV3NeuAcαGgOse4Cer1
Sugimoto, Mamoru,Fujikura, Kazushige,Nunomura, Shigeki,Horisaki, Toshio,Ito, Yukishige,Ogawa, Tomoya
, p. 385 - 388 (2007/10/02)
A first total synthesis of ganglio ganglioside GM1b, α-D-Neup5Ac-(2->3)-β-D-Galp-(1->3)-β-D-GalpNAc-(1->4)-β-D-Galp-(1->4)-β-D-Glcp-(1->1)-Cer, was achieved in a stereocontrolled manner.
