98049-68-4

Upstream product

• 97514-89-1 (3E,5E)-(7S,8R)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-trideca-3,5-dien-1-yne 
• 97514-89-1 (3E,5Z)-(7S,8R)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-trideca-3,5-dien-1-yne 
• 97514-96-0 (3E,5E)-(7S,8R)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-trideca-3,5-dien-1-yne 
• 106031-56-5 2,2-Dimethyl-propionic acid (2S,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-octyl ester 
• 127505-69-5 (2S,3S)-2,3-bis(tert.butyldimethylsiloxy) octanal 
• 91842-16-9 (E)-(S)-7-Bromo-5-(tert-butyl-dimethyl-silanyloxy)-hept-6-enoic acid methyl ester 
• 91842-15-8 (-)-(5S)-methyl 5-<(tert-butyldimethylsilyl)oxy>-6-heptynoate 
• 93398-58-4 (2S,3R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-octan-1-ol 
• 106031-55-4 2,2-Dimethyl-propionic acid (2S,3R)-2,3-dihydroxy-octyl ester 
• 135068-38-1 (2S,3R)-Octane-1,2,3-triol 
• 94235-42-4 epi-lipoxin A₄ 
• 114144-28-4 5S-hydroxy-14,15-LTA₄ 
• 94235-42-4 4-[(2S,3S)-3-((1E,3E,5Z,7E)-(R)-9-Hydroxy-tetradeca-1,3,5,7-tetraenyl)-oxiranyl]-butyric acid 

Relevant academic research and scientific papers

SYNTHESIS OF 5S-HYDROXY-14,15 LTA4 A BIOGENIC PRECURSOR TO THE LIPOXINS

A synthesis of 5S-hydroxy-14,15-LTA4 10 an intermediate in the biosynthesis of the lipoxins is described.

Stereocontrolled Total Synthesis of Lipoxins B

A stereocontrolled total synthesis of six lipoxin B isomers are described.The flexible and stereoselective strategy involves Sharpless asymmetric epoxidation and pinylborane asymmetric reduction to secure the three hydroxyl-bearing stereocenters and a Wittig-type as well as palladium(0)-copper(I) coupling reactions to construct the carbon skeleton of the target molecules.