98049-69-5

Basic information

• Product Name: LIPOXIN B4
• Synonyms: 5(S), 14(R), 15(S)-TRIHYDROXYEICOSA-6E,8Z,10E,12E-TETRAENOIC ACID;LIPOXIN B4;(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid;(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxy-6,8,10,12-icosatetraenoic acid;LXB4;5(S),14(R)-Lipoxin B4;(5S,14R,15S)-5,14,15-Trihydroxy-(6E,8Z,10E,12E)-eicosatetraenoic acid;UXVRTOKOJOMENI-WLPVFMORSA-N
• CAS NO: 98049-69-5
• Molecular Formula: C₂₀H₃₂O₅
• Molecular Weight: 352.47
• Mol File: 98049-69-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 589.4 °C at 760 mmHg
• Flash Point: 324.3 °C
• Appearance: Clear oil dissolved in ethanol
• Density: 1.096 g/cm₃
• Vapor Pressure: 2.39E-16mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: -20°C
• CAS DataBase Reference: LIPOXIN B4(CAS DataBase Reference)
• NIST Chemistry Reference: LIPOXIN B4(98049-69-5)
• EPA Substance Registry System: LIPOXIN B4(98049-69-5)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36
• Hazardous Substances Data: 98049-69-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 98049-69-5 differently. You can refer to the following data:
1. Lipoxins are a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 X 10-10 M.
2. 5(S),14(R)-Lipoxin B4 is a positional isomer of LXA4.

InChI:InChI=1/C20H32O5/c1-2-3-8-14-18(22)19(23)15-10-7-5-4-6-9-12-17(21)13-11-16-20(24)25/h4-7,9-10,12,15,17-19,21-23H,2-3,8,11,13-14,16H2,1H3,(H,24,25)/b6-4-,7-5+,12-9+,15-10+/t17-,18+,19-/m1/s1

Upstream product

• 97514-89-1 (3E,5E)-(7S,8R)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-trideca-3,5-dien-1-yne 
• 97514-89-1 (3E,5Z)-(7S,8R)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-trideca-3,5-dien-1-yne 
• 97514-96-0 (3E,5E)-(7S,8R)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-trideca-3,5-dien-1-yne 
• 106031-56-5 2,2-Dimethyl-propionic acid (2S,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-octyl ester 
• 135068-38-1 (2S,3R)-Octane-1,2,3-triol 
• 94235-42-4 4-[(2S,3S)-3-((1E,3E,5Z,7E)-(R)-9-Hydroxy-tetradeca-1,3,5,7-tetraenyl)-oxiranyl]-butyric acid 
• 127505-69-5 (2S,3S)-2,3-bis(tert.butyldimethylsiloxy) octanal 
• 91842-16-9 (E)-(S)-7-Bromo-5-(tert-butyl-dimethyl-silanyloxy)-hept-6-enoic acid methyl ester 
• 91842-15-8 (-)-(5S)-methyl 5-<(tert-butyldimethylsilyl)oxy>-6-heptynoate 
• 93398-58-4 (2S,3R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-octan-1-ol 
• 106031-55-4 2,2-Dimethyl-propionic acid (2S,3R)-2,3-dihydroxy-octyl ester 
• 114144-28-4 5S-hydroxy-14,15-LTA₄ 

Relevant articles and documents

SYNTHESIS OF 5S-HYDROXY-14,15 LTA4 A BIOGENIC PRECURSOR TO THE LIPOXINS

A synthesis of 5S-hydroxy-14,15-LTA4 10 an intermediate in the biosynthesis of the lipoxins is described.

On the biosynthesis and the structure of lipoxin B

-