98050-85-2

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 90961-26-5 5-(ethoxycarbonyl)-2,6-dimethyl-4-(o-nitrophenyl)-1,4(3,4)-dihydropyrimidine 
• 104765-28-8 2-[(2-nitrophenyl)methylene]-3-oxobutanoic acid,ethyl ester 
• 98050-61-4 6-Hydroxy-2,6-dimethyl-4-(2-nitro-phenyl)-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

3N-substituted 3,4-dihydropyrimidines as agents for treating disorders of cardiovascular system

A 3N-substituted 3,4-dihydropyrimidine derivative of the formula: STR1 wherein R1 is methyl or ethyl, R2 is methyl or ethyl, R is phenyl or substituted phenyl, X is chloro or methyl and pharmaceutically acceptable acid addition salts

Synthesis of Novel Dihydropyrimidines and Tetrahydropyrimidines

Condensation of alkyl 2-acetyl-3-aryl-2-propenoate with acetamidine, benzamidine, guanidine, or 1,1-dimethylguanidine followed by dehydration of the resulting compound 2 with p-TsOH or Al2O3 gave 1,4(3,4)-dihydropyrimidine 3.Regioselective alkoxycarbonylation, acylation, and alkylation of compound 3 with alkyl chloroformate, acyl halide, or alkyl halide in the presence of NaH afforded the series of novel N-substituted 3,4-dihydropyrimidines 4, 5, and 6 in good yield.Stereoselective NaBH4 reduction of the 3,4-dihydropyrimidine hydrochloride 4 provided a singlestereoisomer of 1,2,3,4-tetrahydropyrimidine 7 whose stereochemistry was assigned as cis by X-ray crystallographic analysis.Conversely, the same reduction of the HCl salts of 3 or 6 gave a cis-trans mixture of tetrahydropyrimidines 8.