98066-12-7

Usage

Exhibits various pharmacological effects, including

Anti-inflammatory properties
Anticancer properties
Cardiotonic properties
Has potent cytotoxic effects on cancer cells, making it a potentially valuable compound for the development of new cancer treatments
Demonstrated anti-inflammatory activity, indicating its potential for the treatment of inflammatory diseases
Requires further studies to fully understand its mechanisms of action and potential therapeutic applications.

InChI:InChI=1/C19H20O5/c1-12(15-11-17(20)19(2,3)24-15)8-9-22-14-6-4-13-5-7-18(21)23-16(13)10-14/h4-8,10,15H,9,11H2,1-3H3/b12-8+

Upstream product

• 139870-99-8 (E)-7-<<3-(tetrahydro-5,5-dimethyl-4-hydroxy-2-furanyl)-2-butenyl>oxy>-2H-1-benzopyran-2-one 
• 93741-02-7 (+/-)-(E)-3-(6,6-dimethyl-1,4,7-trioxaspiro<4.4>non-8-yl)-2-buten-1-ol 
• 89983-26-6 ethyl (+/-)-(E)-3-(6,6-dimethyl-1,4,7-trioxaspiro<4.4>non-8-yl)-2-butenoate 
• 6153-06-6 (E)-3-methylpent-2-en-4-yn-1-ol 
• 40834-58-0 (E)-3-methyl-2,4-pentadien-1-ol acetate 
• 1572-08-3 (E)-3-methylpenta-2,4-dien-1-ol 
• 6138-90-5 trans-geranyl bromide 
• 495-02-3 auraptene 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 36414-00-3 (E)-7-<<5-(3,3-dimethyloxiranyl)-3-methyl-2-pentenyl>oxy>-2H-1-benzopyran-2-one 
• 133589-18-1 (+/-)-(E)-7-<<3-<4,5-dihydro-3-(1-hydroxy-1-methylethyl)-5-isoxazolyl>-2-butenyl>oxy>-2H-1-benzopyran-2-one 
• 133589-16-9 (+/-)-(E)-5-<3-(acetyloxy)-1-methyl-1-propenyl>-4,5-dihydro-α,α-dimethyl-3-isoxazolemethanol 
• 133589-19-2 (+/-)-(E)-4,5-dihydro-5-(3-hydroxy-1-methyl-1-propenyl)-α,α-dimethyl-3-isoxazolemethanol 
• 93741-03-8 (+/-)-(E)-8-(3-bromo-1-methyl-1-propenyl)-6,6-dimethyl-1,4,7-trioxaspiro<4.4>nonane 

Downstream Products

• 36413-91-9 geiparvarin 

Relevant academic research and scientific papers

Application of [3+2] nitrile oxide cycloaddition chemistry to the construction of retinoid skeleton and to a new formal synthesis of (±)-ascofuranone and geiparvarin

A flexible approach to the construction of the C-20 retinoid carbon skeleton involving the intermolecular [3+2] cycloaddition of the nitrile oxide derived from a C-14 aldehyde component with both a C-6 diene or enyne dipolarophiles, followed by Mo(CO)6-promoted ring opening of the derived 3,5-disubstituted-isoxazoline or -isoxazole ring systems, has been accomplished. The same strategy has been also successfully applied as a tool for the crucial carbon-carbon bond forming step to the formal synthesis of (±)-ascofuranone and to a new synthesis of geiparvarin.

Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)- furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain

Continuing our study on the structural features of geiparvarin (1), responsible for cytostatic activity, a series of 4,5-dihydro-3(2H)-furanones 10a-f and of 3(2H)-furanones 11a-f as well as 2'',3''-dihydrogeiparvarin (14) have been designed and synthesiz

A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: Application to the formal synthesis of (±)-ascofuranone and geiparvarin

A unified approach to both 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone rings systems centered on a [3+2] nitrile oxide cycloaddition strategy as a tool for the crucial carbon-carbon bond forming step has been successfully applied to the formal synthesis of )(±)-ascofuranone and to a new synthesis of geiparvarin from common intermediates.

Total Syntheses of Fungal Metabolites and Functionalized Furanones

Simple, efficient syntheses of the fungal metabolites colletochlorin D and (+/-)-ascofuranone and one of its stereoisomers are described.Our investigations of functionalized furanones also enabled us to develop a nine-step (22percent overall yield) synthe

A SIMPLE SYNTHESIS OF GEIPARVARIN

A simple, efficient (nine steps, 22percent overall yield) synthesis of geiparvarin is described.