98084-05-0

Basic information

• Product Name: 1,3,3''-tri-N-tosylkanamycin A
• CAS NO: 98084-05-0
• Molecular Weight: 947.072
• Mol File: 98084-05-0.mol

Chemical Properties

• CAS DataBase Reference: 1,3,3''-tri-N-tosylkanamycin A(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,3''-tri-N-tosylkanamycin A(98084-05-0)
• EPA Substance Registry System: 1,3,3''-tri-N-tosylkanamycin A(98084-05-0)

Safety Data

• Hazardous Substances Data: 98084-05-0(Hazardous Substances Data)

Upstream product

• 76550-51-1 6'-N-(benzyloxyarbonyl)-1,3,3''-tri-N-tosylkanamycin A 

Downstream Products

• 134235-74-8 6-O-(3-amino-3-deoxy-α-D-glucopyranosyl)-2-deoxystreptamine (carbonate) 
• 98084-06-1 6'-deamino-6'-hydroxyimino-1,3,3''-tri-N-tosylkanamycin A 

Relevant articles and documents

SYNTHESES OF METHYL 6-DEOXY-6-HYDROXYAMINO-α-D-GLUCOPYRANOSIDE, 6'-N-HYDROXYKANAMYCIN A, AND 6'-N-HYDROXYDIBEKACIN

Methyl-6-deoxy-6-hydroxyamino-α-D-glucopyranoside has been prepared from methyl 6-amino-6-deoxy-α-D-glucopyranoside via oxidation with hydrogen peroxide in the presence of sodium tungstate , followed by reduction with sodium cyanoborohydride in an acidic medium.Acetylation of the Z isomer of 2 gave a nitrile derivative.The above oxidation-reduction procedure was applied to kanamycin A and dibekacin, starting from the corresponding 6'-amino-N-tosyl derivatives.On treatment with sodium in liquid ammonia, 6'-deamino-6'-hydroxyimino-1,3,3''-tri-N-tosylkanamycin A gave the corresponding N-detosyl derivative in good yield with the 6'-aldoxime group remaining intact, but, with 6'-deamino-6'-hydroxyimino-1,3,2',3''-tetra-N-tosyldibekacin, the N-detosyl derivative (17) was obtained only by a very short reaction period.The antibacterial activities of 17 and 6'-N-hydroxydibekacin were demonstrated.