98089-17-9Relevant academic research and scientific papers
Direct access to cobaltacycles via C-H activation: N-chloroamide- enabled room-temperature synthesis of heterocycles
Yu, Xiaolong,Chen, Kehao,Guo, Shan,Shi, Pengfei,Song, Chao,Zhu, Jin
, p. 5348 - 5351 (2017/11/07)
Cobaltacycle synthesis via C-H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. NChloroamides are used as a directing synthon for cobalt-catalyzed roomtemperature C-H activation and construction of heterocycles. Alkynes as coupling partners allow convenient access to isoquinolones, a class of synthetically and pharmaceutically important compounds. The broad substrate scope enables a diverse range of substitution patterns to be incorporated into the heterocyclic scaffold.
A practical one-pot procedure for the synthesis of N-H isoquinolones
Lu, Shaonan,Lin, Yingfu,Zhong, Hongban,Zhao, Kang,Huang, Jianhui
supporting information, p. 2001 - 2005 (2013/04/23)
A practical one-pot procedure for the preparation of N-H isoquinolones has been developed. This 2-step process via C-H activation of N-alkoxyl benzamides and NaH-mediated dealkoxylation reaction has been demonstrated to be a high yielding alternative meth
Pd-catalysed synthesis of isoquinolinones and analogues via C-H and N-H bonds double activation
Zhong, Hongban,Yang, Dan,Wang, Songqing,Huang, Jianhui
supporting information; experimental part, p. 3236 - 3238 (2012/04/11)
An atom economical synthesis of isoquinolinones and analogues via ligand-free Pd-catalysed C-H and N-H double activation has been developed. A series of isoquinolinones were obtained in good to excellent yields. Good regioselectivities were also observed during the activation reactions with unsymmetrical alkynes. A practical one-pot procedure for the preparation of N-H isoquinolinones is also described. The Royal Society of Chemistry 2012.
