98102-30-8

Basic information

• Product Name: 4-fluoroandrostenedione
• Synonyms: 4-fluoroandrostenedione
• CAS NO: 98102-30-8
• Molecular Formula: C19H25 F O2
• Molecular Weight: 304.4
• Mol File: 98102-30-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 425.2°Cat760mmHg
• Flash Point: 161.3°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 1.94E-07mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 4-fluoroandrostenedione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoroandrostenedione(98102-30-8)
• EPA Substance Registry System: 4-fluoroandrostenedione(98102-30-8)

Safety Data

• Hazardous Substances Data: 98102-30-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H25FO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h11-13H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

Upstream product

• 63-05-8 Androstenedione 
• 19793-14-7 4-bromoandrost-4-ene-3,17-dione 
• 98014-30-3 5α-acetoxy-4α-fluoroandrostane-3,17-dione 
• 1649-25-8 4-fluoro-4-androsten-17β-ol-3-one 

Relevant articles and documents

Synthesis and evaluation of analogues of 4-androstene-3,17-dione as aromatase inhibitors

Twenty-three synthetic analogues of 4-androstene-3,17-dione (androstenedione) have been evaluated as inhibitors of human placental microsomal aromatase enzyme. Among the most potent of these compounds were the 4-hydroxy, 6α-fluoro, 6β-fluoro, and 4-fluoroandrostenediones and 4-fluoro-19-nor-4-androstene-3,17-dione. 4-Hydroxy-4-androstene-3,17-dione (4HAD) is an irreversible inhibitor of aromatase in vitro, whereas the four fluoro analogues are reversible inhibitors. 4HAD and 4-fluoro-4-androstene-3,17-dione caused significant regression of the nitrosomethylurea-induced mammary tumor in rats, but the other fluoro derivatives were inactive.

Regiospecific synthesis of 4-fluoro-Δ4,3-keto steroids using caesium fluoroxysulfate

The regiospecific synthesis of two A-ring fluorinated steroids is described.Treatment of a 4-trimethylstannyl Δ4,3-keto steroid with caesium fluorosulfate gave the corresponding fluorinated steroid in good yield; use of the N-fluorodiazabicycli

Electrophilic Fluorination of Unsaturated Systems with the Recently Developed Acetyl Hypofluorite

Acetyl hypofluorite (AcOF, 1) is a relatively new reagent which is prepared in situ from F2 and is an excellent source for electrophilic fluorine.Unlike the other known fluoroxy reagents, it reacts smoothly and quickly at -78 deg C with many types of olef