98102-30-8

Usage

InChI:InChI=1/C19H25FO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h11-13H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

Upstream product

• 19793-14-7 4-bromoandrost-4-ene-3,17-dione 
• 63-05-8 Androstenedione 
• 98014-30-3 5α-acetoxy-4α-fluoroandrostane-3,17-dione 
• 1649-25-8 4-fluoro-4-androsten-17β-ol-3-one 

Relevant academic research and scientific papers

Synthesis and evaluation of analogues of 4-androstene-3,17-dione as aromatase inhibitors

Twenty-three synthetic analogues of 4-androstene-3,17-dione (androstenedione) have been evaluated as inhibitors of human placental microsomal aromatase enzyme. Among the most potent of these compounds were the 4-hydroxy, 6α-fluoro, 6β-fluoro, and 4-fluoroandrostenediones and 4-fluoro-19-nor-4-androstene-3,17-dione. 4-Hydroxy-4-androstene-3,17-dione (4HAD) is an irreversible inhibitor of aromatase in vitro, whereas the four fluoro analogues are reversible inhibitors. 4HAD and 4-fluoro-4-androstene-3,17-dione caused significant regression of the nitrosomethylurea-induced mammary tumor in rats, but the other fluoro derivatives were inactive.

Fluorination of α,β-unsaturated carbonyl compounds using elemental fluorine

Elemental fluorine was successfully added across the double bond of various α,β-unsaturated carbonyl compounds. A necessary ingredient is a presence of alcohol in the solvent mixture. Unlike all other halogen's addition to olefins, fluorine adds itself in

Regiospecific synthesis of 4-fluoro-Δ4,3-keto steroids using caesium fluoroxysulfate

The regiospecific synthesis of two A-ring fluorinated steroids is described.Treatment of a 4-trimethylstannyl Δ4,3-keto steroid with caesium fluorosulfate gave the corresponding fluorinated steroid in good yield; use of the N-fluorodiazabicycli

Solvent dependence of the synthesis and reactions of acetyl hypofluorite

Acetyl hypofluorite (AcOF) has been previously prepared using CFCl3 (CFC-11) as a solvent.It was found that acetonitrile can replace trichlorofluoromethane without sacrificing the efficiency and the regio- and stereo-selectivity of the addition of AcOF to olefins.Most other solvents tested proved to be inadequqte for the synthesis of AcOF, despite the fact that fluorine does react with the dispersed sodium acetate present in the solvent.

Electrophilic Fluorination of Unsaturated Systems with the Recently Developed Acetyl Hypofluorite

Acetyl hypofluorite (AcOF, 1) is a relatively new reagent which is prepared in situ from F2 and is an excellent source for electrophilic fluorine.Unlike the other known fluoroxy reagents, it reacts smoothly and quickly at -78 deg C with many types of olef