98128-60-0Relevant academic research and scientific papers
One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert-butyl esters
Herath, Ananda,Cosford, Nicholas D. P.
supporting information; experimental part, p. 5182 - 5185 (2011/02/27)
The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the corresponding acids in a single microreactor. The protocol was used in the multistep synthesis of pyrrole-3-carboxamides, including two CB1 inverse agonists, directly from commercially available starting materials in a single continuous process.
Novel N,S-phenacyl protecting group and its application for peptide synthesis
Tang, Guo,Ji, Tao,Hu, An-Fu,Zhao, Yu-Fen
experimental part, p. 1907 - 1909 (2009/04/11)
The phenacyl group can be introduced onto amino and thio groups by N,S-alkylation reactions. Conversely, these groups are removed rapidly by employing magnesium in acetic acid. This protecting group was successfully applied to a short peptide synthesis of Boc-L-Cys-Gly-OMe. Georg Thieme Verlag Stuttgart.
