98136-26-6Relevant academic research and scientific papers
Enantioselective Total Synthesis of (+)-Iso-A82775C, a Proposed Biosynthetic Precursor of Chloropupukeananin
Suzuki, Takahiro,Watanabe, Soichiro,Kobayashi, Susumu,Tanino, Keiji
, p. 922 - 925 (2017)
(+)-Iso-A82775C is a proposed biosynthetic precursor of the chloropupukeananin family and an important intermediate for related natural products. The first enantioselective total synthesis of (+)-iso-A82775C (18 steps, 2.2% overall yield) toward the eventual biomimetic total synthesis of chloropupukeananin is described. The key steps are (1) the enantioselective Diels-Alder reaction of 4-bromo-3-hydroxy-2-pyrone with methyl 2-chloroacrylate using cinchonine as an organocatalyst and (2) the anti-selective Cu-mediated SN2′ reaction to afford the axially chiral vinylallene moiety.
Compound and synthesis method and application thereof, and tobacco product
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Paragraph 0042-0049, (2020/05/01)
The invention relates to a compound and a synthesis method and application thereof, and a tobacco product, belonging to the technical field of heterocyclic compounds and cooling agents. The compound disclosed by the invention is 3-(3-pyrrolinyl)-4-methyl-2-pyrone and has a structure as shown in a formula I which is described in the specification. The compound with the structure as shown in the formula I is free of odor and taste, not easy to decompose in dichloromethane, water, ethanol and acetic acid-containing ethanol, and stable in property, has better stability compared with existing alpha-cycloenaminone cooling agents, and can obviously improve the comfort of cigarettes when used for perfuming cigarette tobacco shreds .
