98136-42-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2,6-Dichloropyrimidine-4-carboxamide is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of compounds with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 2,6-Dichloropyrimidine-4-carboxamide is utilized as a precursor in the production of pesticides and other crop protection agents. Its chemical properties make it suitable for the creation of effective and targeted agrochemicals.
Used in Dye Manufacturing:
2,6-Dichloropyrimidine-4-carboxamide is employed as a key component in the manufacturing of dyes for various applications. Its structural features enable the production of dyes with specific color characteristics and properties.
Used in Antitumor Research:
2,6-Dichloropyrimidine-4-carboxamide is used as a subject of study in the field of antitumor research. Its potential to inhibit tumor growth and development makes it a valuable candidate for further investigation and possible application in cancer treatment.
Used in Antiviral Studies:
2,6-DichloropyriMidine-4-carboxaMide is also utilized in antiviral research, where its properties are examined for potential use in combating viral infections. Its structure and reactivity may offer new avenues for the development of antiviral agents.

Upstream product

• 65-86-1 orotic acid 
• 26830-94-4 2,4-dichloropyrimidine-6-carboxylic acid chloride 

Downstream Products

• 1426337-09-8 (S)-methyl 2-((6-carbamoyl-2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)amino)propanoate 
• 1426337-20-3 (S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate 
• 1426335-88-7 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(4-(4-fluorophenoxy)phenyl)pyrimidine-4-carboxamide 
• 1426336-36-8 2-(4-(4-fluorophenoxy)phenyl)-6-(3-(hydroxymethyl)morpholino)pyrimidine-4-carboxamide 
• 1426336-46-0 (S)-6-((3-amino-2-hydroxy-3-oxopropyl)amino)-2-(4-(4-fluorophenoxy)phenyl)pyrimidine-4-carboxamide 
• 1426336-47-1 (S)-3-((6-carbamoyl-2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)amino)-2-hydroxypropanoic acid 
• 1426336-50-6 (S)-2-((1-amino-1-oxopropan-2-yl)amino)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-4-carboxamide 
• 1426336-52-8 (S)-6-((1-amino-1-oxopropan-2-yl)oxy)-2-(4-(4-fluorophenoxy)phenyl)pyrimidine-4-carboxamide 
• 1426337-23-6 (S)-ethyl 2-((6-carbamoyl-2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)oxy)propanoate 
• 1426336-53-9 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(4-((4-(trifluoromethyl)pyridine-2-yl)oxy)phenyl)pyrimidine-4-carboxamide 
• 1426336-01-7 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)pyrimidine-4-carboxamide 
• 1426336-96-0 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(4-(4-cyanophenoxy)piperidin-1-yl)pyrimidine-4-carboxamide 
• 1426336-99-3 6-(((S)-1-amino-1-oxopropan-2-yl)amino)-2-(4-(4-(trifluoromethyl)phenoxy)cyclohex-1-en-1-yl)pyrimidine-4-carboxamide 
• 1426336-93-7 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(4-(4-fluorophenoxy)-3-(hydroxymethyl)phenyl)pyrimidine-4-carboxamide 

Relevant academic research and scientific papers

PYRIDINES AND PYRIMIDINES AND USE THEREOF

The present disclosure provides pyridines and pyrimidines of Formula I and pharmaceutically acceptable salts and solvates thereof: wherein A, G, W1, W2, W3, and R5 are defined as set forth in the specification. The present disclosure also provides uses of the compounds of Formula I and pharmaceutically acceptable salts and solvates thereof. In certain embodiments, Compounds of the present disclosure are useful for treating pain. In another embodiment, Compounds of the present disclosure are useful for treating a disorder responsive to blockade of sodium channels, or alleviating symptoms of the disorder.

Carboxamide Derivatives and Use Thereof

The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: R10 Z-HET-E I-A and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, Rsup

AZASPIRO[4.5] DECANE DERIVATIVES AND USE THEREOF

The invention provides azaspiro[4.5]decane derivatives of Formula (A): and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof, wherein A1, X, A2, Rr, R2', W1, W2/sup

DIBENZAZEPINE DERIVATIVES AND USE THEREOF

The present disclosure provides dibenzazepine derivatives having Formula I or I(A): and the pharmaceutically acceptable salts and solvates thereof, wherein R3a, R3b, R6, V1, V2, Z1, Z2

INDAZOLES AND USE THEREOF

In one aspect, the present disclosure provides indazoles of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R3, R4, R5, R6, Z1, Z2, Z3, and

PYRIDINES AND PYRIMIDINES AND USE THEREOF

The present disclosure provides pyridines and pyrimidines of Formula I and pharmaceutically acceptable salts and solvates thereof: wherein A, G, W1, W2, W3, and R5 are defined as set forth in the specification. The present disclosure also provides uses of the compounds of Formula I and pharmaceutically acceptable salts and solvates thereof. In certain embodiments, Compounds of the present disclosure are useful for treating pain. In another embodiment, Compounds of the present disclosure are useful for treating a disorder responsive to blockade of sodium channels, or alleviating symptoms of the disorder.

ISOQUINOLINE DERIVATIVES AND USE THEREOF

The Invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, or diastereomers thereof: wherein W1, W2, W3, J1, J2, A, R1, R2/su

INDOLE DERIVATIVES AND USE THEREOF

The Invention provides indole derivatives of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1e, R1f, A, X, Y, Z, and W4 are defined as set forth in the specification. The Invention also pro

PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS

The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

PYRIMIDINES AS SODIUM CHANNEL BLOCKERS

The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.