98151-00-9Relevant academic research and scientific papers
An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-γ and IL-4
Zhou, Jian,Zhang, Yongmin,Zhou, Xia,Zhou, Jing,Zhang, Li-He,Ye, Xin-Shan,Zhang, Xiao-Lian
, p. 1605 - 1612 (2008/09/20)
An efficient 'one-pot' approach to the synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives in good yields and with high stereoselectivity was developed. It was found that the synthetic N-alkylated iminosugars showed inhibitory effects on the release of the cytokines IFN-γ and IL-4 from the mouse splenocytes. The preliminary structure-activity relationship was deduced from the activities of N-substituted iminosugars. Apart from the cytokine inhibitory activities, a series of glycosidase inhibitory activities were also examined. The present experimental data demonstrated that synthetic iminosugars might hold potential as immunosuppressive agents.
Stereoselective electrophilic cyclizations of δ-aminoalkenes derived from carbohydrates; synthesis of polyhydroxypiperidines
Huegel, Helmut M.,Hughes, Andrew B.,Khalil, Khadijeh
, p. 1149 - 1155 (2007/10/03)
Electrophilic cyclizations of a carbohydrate-derived δ-aminoalkene were studied. lodocyclizations proceeded with moderate steric control to afford the D-gluco-configured piperidine as the major product, More extensive studies with mercuric salts resulted
