98151-72-5

Upstream product

• 98151-65-6 Acetic acid (3aR,4R,6R,6aR)-6-(2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 69471-49-4 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 98151-64-5 5'-O-acetyl-2-N-(4,4'-dimethoxytrityl)guanosine 
• 132470-74-7 2-N-(4,4’-dimethoxytrityl)-gunaosine 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 98151-67-8 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S,S-diphenyl dithiophosphate 
• 132470-72-5 Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester hexadecyl ester 
• 98151-69-0 2-N-(4,4'-dimethoxytrityl)-2',3'-methoxymethylene-7-methylguanosine-5' S-phenylthiophosphate inner salt 
• 98151-68-9 lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate 
• 132470-69-0 C₄₈H₅₈N₅O₁₅P 
• 132470-70-3 C₅₉H₈₀N₅O₁₅P 

Relevant academic research and scientific papers

Analogues of uridine 5'-diphosphate glucose and guanosine 5'-diphosphate mannose

One-pot coupling of 2',3'-di-O-benzoyl-uridine and 4,5,6,8-tetra-O-acetyl-3,7-anhydro-2-deoxy-D-glycero-D-ido-octitol with appropriate bifunctional phosphoro-, phosphono- and thiophosphonylation reagents gave, after removal of the base-labile protecting groups, analogues of UDP-Glc containg charged phosphate, neutral alkyl- and arylphosphonate and phosphonothioate linkages.In an analogous manner, GDP-Man analogues, in which guanosine and octitol units are similarly linked via phosphate, alkyl phosphate or phosphotriester bonds, were prepared.

A Convenient Method for the Synthesis of P1-(7-Methylguanosine-5')P2-(Ribonucleoside-5')Diphosphates

Chemical synthesis of m7G5'ppNu (Nu=A, G, C, and U) has been achieved by condensation of the protected capping agent (11) with the four common stannylated ribonucleotides (12a-d) in the presence of iodine as activating agent, followe