98154-88-2Relevant academic research and scientific papers
New analogs of somatostatin with unexpected effects in vivo on insulin basal secretion in the rat
Diaz,Cazaubon,Demarne,et al.
, p. 219 - 227 (2007/10/02)
Twenty analogs of somatostatin were synthesized by the alternating solution/solid-phase procedure. The peptide analogs contained taurine, aza-alanine, or D-amino acids as well as multiple deletions. The aim of this study was to obtain analogs that would selectively inhibit insulin or glucagon release. The biological activities were evaluated in vivo in the rat by measuring the effects of the modified somatostatin molecules on basal secretion of insulin and glucagon in the portal vein. Although some selective analogs were found, a few of them having a taurine or an aza-alanine residue in their structure caused a significant increase of insulin secretion. This unexpected phenomenon, for which we do not have an explanation at present, is under investigation.
