98155-18-1

Upstream product

• 98183-20-1 (R)-3-benzyl-2-oxothiazolidine-4-carboxylic acid ethyl ester 
• 98155-23-8 (R)-3-benzyl-2-oxothiazolidine-4-carboxylic acid 

Downstream Products

• 98155-20-5 3-Benzyl-4-[5-(tert-butyl-dimethyl-silanyloxy)-pent-2-ynoyl]-thiazolidin-2-one 
• 105897-41-4 (R)-3-Benzyl-4-[(E)-5-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-pent-2-enoyl]-thiazolidin-2-one 
• 98155-20-5 5-(tert-butyldimethylsilyl)-oxy-1-<4'-(N-benzyl-2'-oxo-thiazolidinyl)>-2-pentyn-1-one 
• 98183-19-8 (R)-3-Benzyl-4-(5-hydroxy-pent-2-ynoyl)-thiazolidin-2-one 
• 105897-36-7 6R-<4'R-(N-benzyl-2'-oxo-thiazolidinyl)>-6-hydroxy-Δ⁴-tetrahydropyran 
• 105897-35-6 6S-<4'R-(N-benzyl-2'-oxo-thiazolidinyl)>-6-hydroxy-Δ⁴-tetrahydropyran 

Relevant academic research and scientific papers

Latrunculins: NMR study, two new toxins and a synthetic approach

A complete 1H and 13C NMR assignment of one of the latrunculins (B) was accomplished with the aid of 2D NMR COSY and CH shift-correlation experiments. The various H-H coupling constants have been determined and a conformation of the macrolide and the tetrahydropyran (THP) ring suggested on basis of the J-values and measured NOE's. The absolute configuration of latrunculin-A(1) was determined on the grounds of its earlier X-ray analysis, and a chemical degradation to a known compound. Two novel latrunculins, -C(3) and -D(4), were isolated from the Red Sea sponge L. magnifica and their structures elucidated. Starting with L-cysteine a synthon for the latrunculins has been synthesized.