98165-40-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,4-DIBROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of antifungal agents. Its unique structure allows for the creation of compounds that can effectively target and combat fungal infections.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2,4-DIBROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE is utilized as a precursor in the production of pesticidal agents. Its incorporation into these products aids in the control of pests that can damage crops and reduce agricultural yields.
Used in Corrosion Inhibition:
1-(2,4-DIBROMOPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE has also been studied for its potential as a corrosion inhibitor across various industries. Its application helps in protecting materials from the damaging effects of corrosion, thereby extending their service life and reducing maintenance costs.

Upstream product

• 126961-68-0 4-Amino-1-[2-(2,4-dibromo-phenyl)-2-oxo-ethyl]-4H-[1,2,4]triazol-1-ium; bromide 
• 288-88-0 1,2,4-Triazole 
• 60208-07-3 α-bromo-2,4-dibromoacetophenone 

Downstream Products

• 126961-74-8 1-(2,4-Dibromo-phenyl)-2-[1,2,4]triazol-1-yl-ethane-1,2-dione 2-oxime 

Relevant academic research and scientific papers

The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation

The control of fungal pathogens is increasingly difficult due to the limited number of effective drugs available for antifungal therapy. In addition, both humans and fungi are eukaryotic organisms; antifungal drugs may have significant toxicity due to the inhibition of related human targets. Furthermore, another problem is increased incidents of fungal resistance to azoles, such as fluconazole, ketoconazole, voriconazole, etc. Thus, the interest in developing new azoles with an extended spectrum of activity still attracts the interest of the scientific community. Herein, we report the synthesis of a series of triazolium salts, an evaluation of their antifungal activity, and docking studies. Ketoconazole and bifonazole were used as reference drugs. All compounds showed good antifungal activity with MIC/MFC in the range of 0.0003 to 0.2/0.0006–0.4 mg/mL. Compound 19 exhibited the best activity among all tested with MIC/MFC in the range of 0.009 to 0.037 mg/mL and 0.0125–0.05 mg/mL, respectively. All compounds appeared to be more potent than both reference drugs. The docking studies are in accordance with experimental results.

Nitrosation of 4-amino-1-phenacyl-1,2,4-triazolium bromides and ω-(1,2,4-triazol-1-yl)acetophenones

The reaction of 4-amino-1-phenacyl-1,2,4-triazolium bromides with an excess of nitrous acid leads to a mixture of the corresponding ω-(1,2,4-triazol-1-yl)-acetophenones and ω-hydroximino-ω-(1,2,4-triazol-1-yl)acetophenones. Products of the latter type are