98186-18-6Relevant academic research and scientific papers
Studies on annelated [1,4]benzothiazines and [1,5]benzothiazepines, V: Synthesis and biological activity of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine
Ambrogi,Giampietri,Grandolini,Perioli,Ricci,Tuttobello
, p. 569 - 577 (2007/10/02)
The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. - All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity. - The tricyclic compounds 7a-j, 8a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.
