98198-24-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block in the development of new drugs, particularly in the area of medicinal chemistry.
Used in Research and Development:
In the field of scientific research, 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol is used as a research compound to study its chemical properties and potential applications. Researchers utilize 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol to explore its reactivity, solubility, and polarity, which can lead to the discovery of new chemical reactions and the development of novel pharmaceutical compounds.
Used in Chemical Synthesis:
4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol is employed as a key component in the synthesis of complex organic molecules. Its presence in the molecular structure can influence the overall properties of the final product, making it an essential component in the creation of new chemical entities with potential applications in various industries.
Used in Material Science:
In the realm of material science, 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol is used as a component in the development of new materials with unique properties. Its incorporation into the molecular structure of these materials can lead to the creation of materials with enhanced properties, such as improved stability, reactivity, or solubility, which can be beneficial in various applications.

InChI:InChI=1/C6H6N4S/c7-4-3-1-2-8-5(3)10-6(11)9-4/h1-2H,(H4,7,8,9,10,11)

Upstream product

• 74895-37-7 2-Cyan-4,4-diethoxybuttersaeurenitril 

Downstream Products

• 1027082-25-2 4-amino-7H-pyrrolo[2,3-d]pyrimidine-2-sulfinic acid 
• 741686-49-7 2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione 
• 769951-32-8 4-amino-7H-pyrrolo[2,3-d]pyrimidine hydrogen sulfate 
• 1053646-61-9 4-phthalimido-7-[3',5'-di-O-(4-methylbenzoyl)-2'-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 443642-29-3 7-deaza-2'-C-methyl-adenosine 
• 1173701-35-3 4-amino-7-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1173701-37-5 1-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,4-dichlorophenyl)urea 
• 1173701-38-6 1-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea 
• 1173701-47-7 1-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,4-dichlorophenyl)urea 
• 1173701-48-8 1-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea 
• 1173701-41-1 N-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide 
• 1173701-39-7 N-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide 
• 1173701-50-2 N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)pyridazine-4-carboxamide 
• 1173701-52-4 N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

Antibacterial activity evaluation of synthetic novel pleuromutilin derivatives in vitro and in experimental infection mice

A series of novel pleuromutilin derivatives embracing 7H-pyrrolo[2,3-d]pyrimidine moiety were synthesized and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative pathogens as well as in vivo efficacy in lethal syste

Diarylureas and diarylamides with pyrrolo[2,3-d]pyrimidine scaffold as broad-spectrum anticancer agents

A series of diarylureas and diarylamides possessing pyrrolo[2,3-d] pyrimidine scaffold was designed and synthesized. The in vitro antiproliferative activities of a selected group of the target compounds against NCI-60 cell line panel were tested and compared with Sorafenib and Imatinib as reference compounds. Most of the compounds showed strong and broad-spectrum antiproliferative activities. Compounds IVa, IVb, and IVd with benzamido moiety at position 4 of the pyrrolo[2,3-d]pyrimidine nucleus, para-disubstituted phenyl ring at N1-position of pyrrolo[2,3-d]pyrimidine scaffold, and urea linker showed strong and broad-spectrum anticancer results with high potencies and efficacies. In addition, the amide derivatives Vb and Vc demonstrated one-digit nanomolar IC50 values over two and one cell line(s), respectively. Amid all the target compounds, compound IVa demonstrated the best results in both one-dose and five-dose testing modes. It showed 109.18% mean % inhibition over the NCI-60 cancer cell line panel at 10 μM concentration, submicromolar 50% inhibitory concentration (IC50) values over eight cell lines of eight different cancer types, and high efficacy with total growth inhibition (TGI) and 50% lethal concentration (LC50) values less than 4.22 μM over three colon, ovarian, and prostate cancer cell lines. It showed superior potency and efficacy to Sorafenib and Imatinib over most of the tested cell lines.

Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of diarylureas and amides having pyrrolo[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of subst

Practical synthesis of a potent hepatitis C virus RNA replication inhibitor

A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline furanose diol intermediate. This is followed by a highly selective glycosidation to couple the C-2 branched furanose epoxide with deazapurine.