98198-24-4

Basic information

• Product Name: 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol
• Synonyms: 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol;4-Amino-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2-thione;4-aMino-1,3-dihydro-2H-Pyrrolo[2,3-d]pyriMidine-2-thione;4-amino-1H-pyrrolo[2,3-d]pyrimidine-2(7H)-thione;4-amino-1,3-dihydropyrrolo[2,3-d]pyrimidine-2-thione
• CAS NO: 98198-24-4
• Molecular Formula: C₆H₆N₄S
• Molecular Weight: 166.2
• Product Categories: Heterocycle intermediates;Pyrimidines
• Mol File: 98198-24-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 502.545 °C at 760 mmHg
• Flash Point: 257.73 °C
• Appearance: /
• Density: 1.81
• Vapor Pressure: 8.48E-05mmHg at 25°C
• Refractive Index: 1.926
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.34±0.40(Predicted)
• CAS DataBase Reference: 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol(98198-24-4)
• EPA Substance Registry System: 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol(98198-24-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 98198-24-4(Hazardous Substances Data)

Usage

General Description

4-Amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol, also known as CAS Number 23458-76-4, is a chemical compound belonging to the category of molecules containing a pyrrolo[2,3-d]pyrimidine moiety, which is a pyrrolopyrimidine with a pyrimidine ring fused to the pyrrole ring. This chemical is characterized by a strong smell and is typically yellow to orange in appearance. It has applications in various commercial and industrial fields, especially in the medical and pharmaceutical industry. Its exact usage may depend upon its chemical properties such as its reactivity, solubility, polarity, and other factors. It's important to handle this compound with care, adhering to appropriate safety and handling precautions as it may cause harm if improperly handled or ingested.

InChI:InChI=1/C6H6N4S/c7-4-3-1-2-8-5(3)10-6(11)9-4/h1-2H,(H4,7,8,9,10,11)

Upstream product

• 74895-37-7 2-Cyan-4,4-diethoxybuttersaeurenitril 

Downstream Products

• 1173701-35-3 4-amino-7-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1173701-37-5 1-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,4-dichlorophenyl)urea 
• 1173701-38-6 1-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea 
• 1173701-47-7 1-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,4-dichlorophenyl)urea 
• 1173701-48-8 1-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea 
• 1173701-41-1 N-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide 
• 1173701-39-7 N-(4-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide 
• 1173701-50-2 N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)pyridazine-4-carboxamide 
• 1173701-52-4 N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide 
• 1173701-49-9 N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide 
• 1173701-53-5 N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-3-(4-methyl-1H-imidazol-1-yl)-5-(trif luoromethyl)benzamide 
• 1173701-31-9 N-(7-(4-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide 
• 1173701-33-1 N-(7-(4-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide 
• 1173701-43-3 N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide 

Relevant articles and documents

Antibacterial activity evaluation of synthetic novel pleuromutilin derivatives in vitro and in experimental infection mice

A series of novel pleuromutilin derivatives embracing 7H-pyrrolo[2,3-d]pyrimidine moiety were synthesized and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative pathogens as well as in vivo efficacy in lethal syste

Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of diarylureas and amides having pyrrolo[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of subst