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98198-48-2

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98198-48-2 Usage

Chemical Properties

Light yellow Cryst

Uses

2-Amino-5-bromo-4-methylpyridine is used as a pharmaceutical intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 98198-48-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,1,9 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 98198-48:
(7*9)+(6*8)+(5*1)+(4*9)+(3*8)+(2*4)+(1*8)=192
192 % 10 = 2
So 98198-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H7BrN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)/p+1

98198-48-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (44623)  2-Amino-5-bromo-4-methylpyridine, 97%   

  • 98198-48-2

  • 1g

  • 196.0CNY

  • Detail
  • Alfa Aesar

  • (44623)  2-Amino-5-bromo-4-methylpyridine, 97%   

  • 98198-48-2

  • 5g

  • 767.0CNY

  • Detail
  • Alfa Aesar

  • (44623)  2-Amino-5-bromo-4-methylpyridine, 97%   

  • 98198-48-2

  • 25g

  • 3629.0CNY

  • Detail
  • Aldrich

  • (576786)  2-Amino-5-bromo-4-methylpyridine  98%

  • 98198-48-2

  • 576786-1G

  • 214.11CNY

  • Detail
  • Aldrich

  • (576786)  2-Amino-5-bromo-4-methylpyridine  98%

  • 98198-48-2

  • 576786-5G

  • 918.45CNY

  • Detail
  • Aldrich

  • (576786)  2-Amino-5-bromo-4-methylpyridine  98%

  • 98198-48-2

  • 576786-25G

  • 2,861.82CNY

  • Detail

98198-48-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-bromo-4-methylpyridine

1.2 Other means of identification

Product number -
Other names 5-bromo-4-methylpyridin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98198-48-2 SDS

98198-48-2Relevant articles and documents

Preparation of a novel 1,4-pyridylphenylene derivative for synthesis of new rigid backbone conjugated polymers

Wasgindt,Klemm

, p. 103 - 110 (1999)

High yield synthesis of 1,4-bis-(2-bromo-4-methyl-5-pyridyl)-benzene as monomer for conjugated polymers.

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 1. Evolution of Enabling Strategies

Fox, Richard J.,Tripp, Jonathan C.,Schultz, Mitchell J.,Payack, Joseph F.,Fanfair, Dayne D.,Mudryk, Boguslaw M.,Murugesan, Saravanababu,Chen, Chung-Pin H.,La Cruz, Thomas E.,Ivy, Sabrina E.,Broxer, Sévrine,Cullen, Ryan,Erdemir, Deniz,Geng, Peng,Xu, Zhongmin,Fritz, Alan,Doubleday, Wendel W.,Conlon, David A.

, p. 1095 - 1109 (2017/08/23)

The development of two enabling routes that led to the production of >1000 kg of BMS-663068 (3) is described. The route identified for the initial 100 kg delivery to support development activities and initial clinical trials involved the conversion of 2-amino-4-picoline to the parent active pharmaceutical ingredient (API), followed by pro-drug installation and deprotection. To eliminate the problematic isolation of the parent API and synthesis of di-t-butyl(chloromethyl)phosphate, a second-generation pro-drug installation route was developed which involved the conversion of a late-stage common intermediate to an N(1)-thioether derivative followed by chloromethylation, displacement with di-t-butylpotassium phosphate, and deprotection. This second strategy resulted in the multikilogram scale preparation of the API in 14 linear steps and ~7% overall yield.

A mild method for the regioselective bromination of 2-aminopyridines

Xu, Tong,Zhou, Wen,Wang, Jing,Li, Xue,Guo, Jun-Wen,Wang, Bin

supporting information, p. 5058 - 5061 (2015/01/08)

An efficient and regioselective bromination of 2-aminopyridines was developed. The environmental friendly bromination occurs under mild and clean conditions using readily available 1-butylpyridinium bromide as the bromine source and hydrogen peroxide as the green oxidant.

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