Welcome to LookChem.com Sign In|Join Free
  • or
Flesinoxan is a novel heterobicyclic-aryl-piperazine that is chemically distinct from buspirone-like compounds. It is a highly selective 5-HT1A receptor agonist with significantly weaker affinity for α1-adrenergic, dopamine 2, and dopamine 3 receptors compared to buspirone. The highest density of flesinoxan binding sites in the brain is found in the hippocampus, dentate gyrus, lateral septum, and entorrhinal cortex. Flesinoxan has demonstrated greater potency in reducing anxiety in several animal paradigms and has shown effectiveness in Phase II studies for relieving symptoms of generalized anxiety disorder.
Used in Pharmaceutical Industry:
Flesinoxan is used as an anxiolytic agent for its effectiveness in reducing anxiety symptoms in various animal paradigms and its demonstrated efficacy in Phase II studies for generalized anxiety disorder.
Flesinoxan is used as a potential treatment for major depressive disorder due to its ongoing clinical development and its modulation of the 5-HT1A receptor, which plays a role in mood regulation.
Flesinoxan is used as a selective 5-HT1A receptor agonist for its much weaker affinity for other receptors, such as α1-adrenergic, dopamine 2, and dopamine 3 receptors, which may contribute to its therapeutic potential with fewer side effects compared to buspirone.
In Clinical Development:
Flesinoxan is used in the development of treatments for generalized anxiety disorder, with Phase II studies showing its effectiveness in relieving symptoms and being better than placebo.
Flesinoxan is used in the development of treatments for major depressive disorder, as it is currently under clinical development for this purpose.

98206-10-1

Post Buying Request

98206-10-1 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

98206-10-1 Usage

Biological Activity

Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects.

Check Digit Verification of cas no

The CAS Registry Mumber 98206-10-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,2,0 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98206-10:
(7*9)+(6*8)+(5*2)+(4*0)+(3*6)+(2*1)+(1*0)=141
141 % 10 = 1
So 98206-10-1 is a valid CAS Registry Number.
InChI:InChI=1/C22H26FN3O4/c23-17-6-4-16(5-7-17)22(28)24-8-9-25-10-12-26(13-11-25)19-2-1-3-20-21(19)29-15-18(14-27)30-20/h1-7,18,27H,8-15H2,(H,24,28)/t18-/m0/s1

98206-10-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-N-[2-[4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl]ethyl]benzamide

1.2 Other means of identification

Product number -
Other names UNII-8HV9S83FNY

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98206-10-1 SDS

98206-10-1Downstream Products

98206-10-1Relevant academic research and scientific papers

The synthesis of (+)- and (-)-flesinoxan: Application of enzymatic resolution methodology

Ennis,Ghazal

, p. 6287 - 6290 (2007/10/02)

The synthesis of (±)-flesinoxan was carried out in seven steps starting from catechol. An enzymatic resolution was utilized to prepare each enantiomer. Based upon the known preferences of the enzyme system used, we have assigned the (R)-configuration to the (+)-flesinoxan isomer.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 98206-10-1