98258-75-4

Upstream product

• 63909-29-5 (E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 

Downstream Products

• 1622204-06-1 5-((2-(4-(4-fluoropiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 
• 1622204-07-2 6-methoxy-N-methyl-5-((2-(4-(4-(pyrrolidin-1-yl)piperidin-1-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide 
• 1622204-08-3 5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 
• 1622204-09-4 5-((2-(4-(((3S,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1,4-indole-1-carboxamide 
• 1622204-10-7 5-((2-(4-(2-(4-ethylpiperazin-1-yl)ethyl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 
• 1622204-11-8 5-((2-(4-(2-(4-hydroxypiperidin-1-yl)ethoxy)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 
• 1622204-13-0 5-((2-(4-((1-(2-hydroxyethyl)piperidin-4-yl)oxy)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 
• 1622206-01-2 C₂₄H₂₁ClN₄O₄ 
• 1622206-02-3 C₂₅H₂₃ClN₄O₄ 
• 1622206-03-4 C₂₅H₂₃ClN₄O₅ 
• 1622205-36-0 C₃₃H₃₇N₅O₇ 
• 1622205-37-1 C₂₈H₂₉N₅O₅ 
• 1622204-00-5 6-methoxy-N-methyl-5-((2-(4-(piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide 
• 1622204-01-6 5-((2-(4-(1-ethylpiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 

Relevant academic research and scientific papers

MONOCYCLIC PYRIDINE DERIVATIVE

The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or —CH2—; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.

EFFICIENT SYNTHESES OF (E)-4-HYDROXY-5-METHOXY- AND (E)-5-HYDROXY-4-METHOXY-2,β-DINITROSTYRENES

The key to efficient syntheses of the title compounds is chemoselective CF3CO2H debenzylation.The benzyl protecting group is necessary for regiospecific nitration.