98267-09-5

Basic information

• Product Name: 1-[(8-Methoxy-5-quinolinyl)sulfonyl]aziridine
• Synonyms: 1-[(8-Methoxy-5-quinolinyl)sulfonyl]aziridine
• CAS NO: 98267-09-5
• Molecular Formula: C12H12N2O3S
• Molecular Weight: 0
• Mol File: 98267-09-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(8-Methoxy-5-quinolinyl)sulfonyl]aziridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(8-Methoxy-5-quinolinyl)sulfonyl]aziridine(98267-09-5)
• EPA Substance Registry System: 1-[(8-Methoxy-5-quinolinyl)sulfonyl]aziridine(98267-09-5)

Safety Data

• Hazardous Substances Data: 98267-09-5(Hazardous Substances Data)

Usage

Type of compound

Aziridine derivative

Structural feature

Contains a quinoline sulfonyl group

Potential use

Antitumor agent

Activity

Exhibits cytotoxic activity against various cancer cell lines in vitro

Mechanism of action

Inhibits tubulin polymerization

Additional effect

Induces apoptosis in cancer cells

Current status

Research is ongoing

Goal

Developing it into a novel chemotherapy agent for treating cancer

Upstream product

• 151-56-4 ethyleneimine 
• 90429-62-2 8-methoxyquinoline-5-sulfonyl chloride 

Relevant articles and documents

SYNTHESIS OF N-(8-METHOXY-5-QUINOLYLSULFONYL)AZIRIDINE AND ITS REACTIONS WITH SECONDARY AMINES. PMR SPECTRA AND STRUCTURES OF THE DERIVATIVES OBTAINED

A method for the synthesis of a new fluorescent derivative of ethyleneimine, viz., N-(8-methoxy-5-quinolylsulfonyl)-aziridine, starting from 8-methoxyquinoline-5-sulfonyl chloride was developed.The quinolylsulfonylaziridine reacts smoothly with secondary aliphatic amines to give 8-methoxy-5-quinolinesulfonamides.In a study of the PMR spectra of these compounds it was established that significant deshielding of the 4-H proton (0.8 ppm) and a substantial increase (by 0.8 ppm) in 3J(6,7) are characteristic signs of the introduction of aziridinylsulfonyl or N-(2-N-dialkylamino)sulfonamido substituents into the 5 position of 8-methoxyquinoline.