98269-23-9

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• 104-92-7 1-bromo-4-methoxy-benzene 
• 66943-05-3 1,4,7,10-tetraoxa-15-azacyclopentadecane 
• 623-12-1 4-chloromethoxybenzene 
• 98269-30-8 diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate 
• 104-94-9 4-methoxy-aniline 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 19721-54-1 2-[(2-hydroxyethyl)-(4-methoxyphenyl)amino]ethanol 
• 80322-82-3 triethyleneglycol dimesylate 

Relevant academic research and scientific papers

Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation

Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II:

Synthesis of N-aryl-aza-crown ethers via Pd-catalyzed amination reactions of aryl chlorides with aza-crown ethers

The Pd2(dba)3/P(i-BuNCH2CH 2)3N (1) catalyst system effectively catalyzes the coupling of aza-crown ethers with electronically diverse aryl chlorides, affording N-aryl-aza-crown ethers in good yields. The Pd2(dba) 3/P(i-BuNCH2)3CMe (2) catalyst system containing the more constrained bicyclic triaminophosphine is useful for aryl chlorides possessing base-sensitive ester, nitro, and nitrile functional groups. Graphical Abstract

Efficient synthesis of N-Aryl-aza-crown ethers via palladium-catalyzed amination

N-Aryl-aza-crown ethers were efficiently prepared by reaction of an aza-crown ether with an aryl bromide via a palladium-catalyzed amination. The combination of Pd2(dba)3 and a biphenyl-based electron-rich bulky monophosphine is effective for catalyzing the coupling of 1-aza-15-crown-5 with both electron-deficient and electron-rich aryl bromides under mild conditions. N-Aryl-aza-crown ethers were produced in 75-91% yields. N-Aryl-aza-crown ethers with o-aryl substituents can also be synthesized using this catalyst system, albeit in lower yields (~40%).