98269-27-3

Upstream product

• 26150-06-1 tetraethylene glycol monoallyl ether 
• 98-59-9 p-toluenesulfonyl chloride 
• 112-60-7 Tetraethylene glycol 

Downstream Products

• 1431328-81-2 1-triethoxysilyl-(3-tetraethyleneglycoxy-ω-tosyl)propane 

Relevant academic research and scientific papers

NOVEL TRIAZINE COMPOUND, ALL-SOLID-STATE POLYMER ELECTROLYTE COMPOSITION AND USE THEREOF

The present invention relates to a novel triazine compound represented by chemical formula 1, an all-solid-state polymer electrolyte composition comprising the same as a cross-linking agent and uses thereof. More specifically, the triazine compound effectively inhibits crystallization of a plasticizer at a low temperature (room temperature) to show significantly improved ion conductivity, and can realize significantly improved electrochemical stability and excellent battery properties, thereby being usefully used as an all-solid-state polymer electrolyte composition such as a lithium-polymer secondary battery, a dye-sensitized solar cell, etc.COPYRIGHT KIPO 2018

TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells

N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide (CTB) is a small molecule that functions by altering the chromatin architecture to modulate gene expression. We report a new CTB derivative with increased solubility and demonstrate CTB's functionality by conjugating it on the recently established NanoScript platform to enhance gene expression and induce stem cell differentiation. NanoScript is a nanoparticle-based artificial transcription factor that emulates the structure and function of transcription factor proteins (TFs) to effectively regulate endogenous gene expression. Modifying NanoScript with CTB will more closely replicate the TF structure and enhance CTB functionality and gene expression. To this end, we first conjugated CTB onto NanoScript and initiated a time-dependent increase in histone acetyltransferase activity. Next, because CTB is known to trigger the pathway involved in regulating Sox9, a master regulator of chondrogenic differentiation, we modifed a Sox9-specific NanoScript with CTB to enhance chondrogenic gene activity and differentiation. Because NanoScript is a tunable and robust platform, it has potential for various gene-regulating applications, such as stem cell differentiation.

Preparation of bifunctional mesoporous silica nanoparticles by orthogonal click reactions and their application in cooperative catalysis

The synthesis of bifunctional mesoporous silica nanoparticles is described. Two chemically orthogonal functionalities are incorporated into mesoporous silica by co-condensation of tetraethoxysilane with two orthogonally functionalized triethoxyalkylsilanes. Post-functionalization is achieved by orthogonal surface chemistry. A thiol-ene reaction, Cu-catalyzed 1,3-dipolar alkyne/azide cycloaddition, and a radical nitroxide exchange reaction are used as orthogonal processes to install two functionalities at the surface that differ in reactivity. Preparation of mesoporous silica nanoparticles bearing acidic and basic sites by this approach is discussed. Particles are analyzed by solid state NMR spectroscopy, elemental analysis, infrared-spectroscopy, and scanning electron microscopy. As a first application, these particles are successfully used as cooperative catalysts in the Henry reaction. Cooperative clicking: Bifunctional mesoporous silica particles were synthesized by orthogonal surface chemistry. A thiol-ene reaction, a copper-catalyzed 1,3-dipolar cycloaddition and a radical nitroxide exchange reaction were used as orthogonal processes for the introduction of the acid and base functionalities (see scheme). Catalytic activities of these bifunctionalized inorganic/organic hybrid materials were studied on the Henry reaction. Copyright

Design of functionalized cellulosic honeycomb films: Site-specific biomolecule modification via "click chemistry"

Value-added materials from naturally abundant polymers such as cellulose are of significant importance. In particular, cellulosic open-framework structures with controlled chemical functionality of the internal surface have great potential in many biosens

Quantification of grafted poly(ethylene glycol)-silanes on silicon by time-of-flight secondary ion mass spectrometry

Silicon grafted monodisperse poly(ethylene glycol) (PEG) silanes with various PEG chain lengths and mixtures of these were systematically analyzed with static time-of-flight secondary ion mass spectrometry (TOF-SIMS). The mass spectra show differences in the various relative signal intensities, an observation that was used to elucidate important aspects of the grafting process. The relationship between PEG-silane fragment ion abundances and Si+ ion abundances were used to (i) qualitatively describe layer thicknesses of grafted mixtures of PEG-silanes on silicon, (ii) construct a calibration curve from which PEG chain length (or molecular mass) can be determined and (iii) quantitatively determine surface mixture compositions of grafted monodisperse PEG-silanes of different chain lengths (3, 7 and 11 PEG units). The results suggest that discrimination does take place in the adsorption process. The PEG-silane with the shorter PEG chain is discriminated for mixtures containing PEG3-silane, whereas the PEG-silane with the longer PEG chain is discriminated in PEG7/PEG11-silane mixtures. The origin of this difference in adsorption behavior is not well understood. Aspects of the grafting process and the TOF-SIMS analyses are discussed. Copyrigh

Examples of amphitropic polymers: Monolayer film, Langmuir-Blodgett film and liquid-crystalline properties of some polymeric amphiphiles containing cholestanol moieties and those of some closely related non-polymeric amphiphiles

A range of alternating copolymers were prepared by free-radical-initiated copolymerizations of maleic anhydride with a series of α-alkenes containing cholestanyl moieties. Derivatives of these copolymers were prepared by reacting the anhydride residues with methanol, water, dimethylamine and/or morpholine. A related series of non-polymeric amphiphiles containing steroid moieties was also prepared. Isotherms were measured for monolayers of the various polymers and the various non-polymeric amphiphiles on water and, where possible, Langmuir-Blodgett (LB) multilayers were prepared. The majority of the materials gave good isotherms (relatively steep with collapse pressures >40 mN m-1) indicating that the monolayers were ordered and, as determined by the detection of Bragg peaks by X-ray diffraction, Y-type LB films with regular layer structures. Appropriate materials were also examined, by optical microscopy and differential scanning calorimetry (DSC), for possible liquid-crystalline properties. Four polymers and one non-polymeric amphiphile exhibited smectic A mesophases. Another non-polymeric amphiphile exhibited a cholesteric mesophase. Thus, examples were found of amphitropic polymers and non-polymeric amphiphiles which can form organised molecular arrangements both because they are amphiphilic and because they contain mesogens.

Ring-Side-Arm Cooperativity in Cation Inclusion Complexes of 12-Membered Ring Lariat Ethers: Effect of Side-Arm Chain Length and a Clarification of Long-Side-Arm Binding Strengths

The alkali metal and ammonium cation binding properties of N-pivot, 12-crown-4 lariat ethers are recorded here.A reinvestigation of N-pivot lariat ethers having (CH2CH2O)nCH3 side arms is presented, and data are reported for fresh samples of these long chain compounds.Details of the X-ray crystal structures obtained for N-aza-12-crown-4 are reported.The complex crystallizes in the tricyclic space group P1 with cell constants a = 8.712 (2) Angstroem, b = 8.694 (3) Angstroem, c = 11.740 (3) Angstroem, α = 111.44 (2) deg, β = 90.76 (2) deg, γ = 103.50 (2) deg, and Z = 2 for Dc = 1.591 gcm-1.Least-squares refinement based on 3723 observed reflections led to a final conventional R value of 0.052.All of the lariat ether donors bind to the alkali metal cation, with the macroring in the crown conformation.The 12-crown-4 system behaves, in many ways, like the 15- and 18-membered ring analogues.The presence of an octakis(ethyleneoxy) side arm does not diminish cation binding strength in this series as reported for the 15- and 18-membered ring compounds.Indeed, the fall off in binding constants previously reported for the longest chain examples of the latter families now appears to be due to sample decomposition rather than solvent encumbrance.