98291-96-4Relevant academic research and scientific papers
A highly efficient synthesis of [1-13C, 18O]- and [1-13C, 2H2]-glycerol for the elucidation of biosynthetic pathways
Siskos, Alexandros P.,Hill, Alison M.
, p. 789 - 792 (2003)
Labeled glycerol is a widely used biochemical probe to investigate biosynthetic pathways. A highly efficient synthesis of [1-13C, 18O]- and [1-13C, 2H2]-glycerol is described in which the 13C label is introduced using cyanide. The 18O label was introduced by a Pinner synthesis and reduction of the ester 5 allowed incorporation of the 2H labels.
