98294-53-2 Usage
Uses
Used in Oncology:
3-(1-Methyl-piperidin-4-yl)-1H-indazole is used as an anticancer agent for its ability to inhibit tumor growth and sensitize cancer cells to chemotherapy. By selectively inhibiting the protein deubiquitinase USP14, it can potentially enhance the effectiveness of conventional cancer treatments and improve patient outcomes.
Used in Neurodegenerative Disease Research:
3-(1-Methyl-piperidin-4-yl)-1H-indazole is used as a research compound for investigating its potential role in modulating neurodegenerative diseases such as Parkinson's and Alzheimer's. Its ability to target protein degradation pathways may provide valuable insights and contribute to the development of new strategies for treating these diseases.
Used in Drug Development:
3-(1-Methyl-piperidin-4-yl)-1H-indazole is used as a lead compound in the development of new therapeutic agents targeting the protein deubiquitinase USP14. Further research and development of UMI-77 and related compounds may lead to the discovery of novel drugs with improved efficacy and safety profiles for the treatment of various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 98294-53-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,2,9 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 98294-53:
(7*9)+(6*8)+(5*2)+(4*9)+(3*4)+(2*5)+(1*3)=182
182 % 10 = 2
So 98294-53-2 is a valid CAS Registry Number.
98294-53-2Relevant academic research and scientific papers
ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA
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Page/Page column 41-42, (2010/02/06)
This invention relates to novel compounds which up-regulate LDL receptor (LDL-r) expression. and to processes for their preparation, pharmaceutical compositions containing them and their medical use. More particularly, this invention relates to novel aromatic piperidines of formula (I) and their use in therapy. wherein Ar1 is substituted, by at least one R1 group selected from: -O(CRaRb)nC(O)NRXRy, -O(CH2)nCN, -O(CH2)nO(CH2)mOR2, -O(CH2)nCO2R2, -OS02NRxRy, -OSO2(CH2)pCH3, -(CRaRb)nC(O)NRXRy, -(CH2)nCN, -(CH2)nO(CH2)mOR2, -(CH2)nCO2R2, -(CH2)nC(O)R2, - SO2NRxRy, -SO2(CH2)pCH3, -CH=CHC(O)NRxRy, -CH=CHCN, -CH=CHCO2R2, -CO2R2, - C(O)R2, -C(O)NRxRy and C2-5alkenyl.
Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
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, (2008/06/13)
Novel 3-(piperidinyl- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for treating psychoses, treating depression, alleviating pain, treating convulsions and treating hypertension utilizing compounds or compositions thereof are disclosed.
