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983-28-8

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983-28-8 Usage

General Description

The chemical "(3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate" is a compound with a complex molecular structure. It consists of a steroid backbone with a hydrazine group attached to the 17th carbon atom and an acetate group attached to the 3rd carbon atom. The compound is a derivative of androst-5-en-3-ol, which is a hormone precursor and a key molecule in the biosynthesis of androgens and estrogens. The presence of the hydrazine group makes this compound a potential intermediate for the synthesis of various pharmaceuticals or research chemicals. The specific arrangement of atoms and functional groups in this compound makes it potentially valuable in the development of new drugs or in the study of steroid biology.

Check Digit Verification of cas no

The CAS Registry Mumber 983-28-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 983-28:
(5*9)+(4*8)+(3*3)+(2*2)+(1*8)=98
98 % 10 = 8
So 983-28-8 is a valid CAS Registry Number.

983-28-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name [(3S,8R,9S,10R,13S,14S,17E)-17-(carbamoylhydrazinylidene)-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] acetate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:983-28-8 SDS

983-28-8Relevant articles and documents

Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents

Cui, Hai-Wei,Peng, Shihong,Gu, Xiang-Zhong,Chen, Huang,He, Yuan,Gao, Wei,Lv, Fang,Wang, Jin-Hua,Wang, Yan,Xie, Jia,Liu, Ming-Yao,Yi, Zhengfang,Qiu, Wen-Wei

, p. 126 - 137 (2017/12/26)

A series of D-ring fused 1,2,3-thiadiazole DHEA derivatives were synthesized and investigated for their activity against the growth of various tumor cell lines using the sulforhodamine B (SRB) assay. It is amazing that for these compounds, T47D cell line was much more sensitive than other tumor cell lines. The most potent saturated N-heterocyclic derivatives showed similar antitumor effect with the positive control compound ADM (adriamycin) on T47D cells, that was 44–60 folds more potent than the lead compound DHEA. Most compounds with potent antitumor activity displayed low toxicity on normal human fibroblasts (HAF). Especially compound 25 (CH33) showed an IC50 of 0.058 μM on T47D cells and its selectivity index (SI) between HAF and T47D was 364, which was 214 folds better than ADM (SI = 1.7). The apoptosis, colony formation and transwell migration assays of 25 were performed on T47D cell line. The primary mechanism study showed that 25 caused a dose-dependent induction of apoptosis, and induced phosphorylation of EphA2 and EphB3 in T47D cells. The in vivo antitumor effect of 25 was also observed in T47D tumor-bearing mice without obvious toxicity.

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