98315-33-4Relevant academic research and scientific papers
Preparation of Sulfur-Containing Optically Active Secondary Alcohols Based on Pichia farinosa-Catalyzed anti-Prelog-Rule Reduction as the Key Step
Ohtsuka, Yoshikazu,Katoh, Osamu,Sugai, Takeshi,Ohta, Hiromichi
, p. 483 - 491 (2007/10/03)
A Pichia farinosa IAM 4682 mediated reduction of sulfur containing ketones afforded secondary alcohols with (R)-absolute configuration. For example, 4-(phenylthio)-2-butanone and 4-(phenylsulfonyl)-2-butanone afforded (R)-4-(phenylthio)-2-butanol (91%ee) in 90% yield and (R)-4-(phenylsulfonyl)-2-butanol (97%ee) in 94% yield, respectively. In the case that the ee of the product was not satisfactory, any contaminating (S)-enantiomer was selectively oxidized by Rhodococcus rhodochrous IFO 15564 to leave pure (R)-enantiomer. The substrate specificity of Pichia farinosa-mediated reduction and Rhodococcus rhodochrous-mediated oxidation was further examined.
Synthesis of the dioxabicyclononane unit of tirandamycin
Kelly,Chandrakumar,Cutting,et al.
, p. 2173 - 2176 (2007/10/02)
A seven-step synthesis of (±)-3b, an advanced, common intermediated for construction of the dioxabicyclononane units of both tirandamycin and streptolydigin is described. Conversion of 3b to the fully developed fragment of tirandamycin is also reported.
