98320-09-3Relevant academic research and scientific papers
1,4-thiazine derivative, and cardiotonic agent comprising it as effective component
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, (2008/06/13)
A novel 1,4-thiazine derivative represented by the formula I, a pharmaceutically acceptable acid addition salt thereof, a process for preparation thereof and a cardiotonic agent comprising it as an effective component; STR1 wherein R1 and Rsub
Thiazole derivatives and medical compositions thereof
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, (2008/06/13)
A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof STR1 wherein R1 represents --COOR4, STR2 or cyano wherein R4 represents hydr
1,4-Thiazine derivatives
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, (2008/06/13)
Disclosed is a novel 1,4-thiazine derivatives represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof: STR1 wherein R1, R2 and R3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II: STR2 wherein R1, R2 and R3 are as defined above, A represents a group STR3 in which X represents a halogen atom and n is a number of 1 to 3, and X' represents a halogen atom which may be the same as or different from X, and reacting the compound of the general formula II with sulfur at elevated temperature or stirring the compound of the general formula II in a solution system comprising zinc and a carboxylic acid. Further disclosed is a cardiotonic agent comprising a pharmaceutically acceptable excipient and, as the active component thereof, an effective amount of the novel 1,4-thiazine derivative having the general formula I.
