98320-24-2

Upstream product

• 98320-26-4 [10-Methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]-acetic acid methyl ester 
• 59743-84-9 10-methoxy-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one 
• 155788-42-4 (E)-<7-<(Diethoxyphosphoryl)oxy>-8-methoxy-5H-benzocyclohepten-5-yliden>essigsaeure-methylester 
• 155788-53-7 (E)-<7-<(2,2-Diisopropoxyethyl)thio>-8-methoxy-5H-benzocyclohepten-5-yliden>essigsaeure-methylester 
• 155788-43-5 (E)-<7-<(2,2-Diethoxyethyl)thio>-8-methoxy-5H-benzocyclohepten-5-yliden>essigsaeure-methylester 
• 155788-44-6 (E)-<7-<(Formylmethyl)thio>-8-methoxy-5H-benzocyclohepten-5-yliden>essigsaeure-methylester 
• 155788-39-9 8-Methoxy-7-oxo-7H-benzocyclohepten-5-essigsaeure-methylester 
• 6322-85-6 6-Methoxy-7H-benzocyclohepten-7-on 
• 643-79-8 o-phthalic dicarboxaldehyde 

Relevant academic research and scientific papers

Stereoselective syntheses of (Z)-(10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)aceti c acid

Two stereoselective syntheses for the antiinflammatory compound 1 ((Z)-isomer) are described. In the first approach (Strategy A, Scheme 1) the stereoselective synthesis of 1 was realized via the bicyclic compound 11 under thermodynamic conditions, followe

4H-benzo(4,5)cyclohepta(1,2-B)thiophene derivatives

α-[5H-dibenzo[a,d]cyclohepten-5-ylidene]-carboxylic acids e.g. of formula I STR1 wherein R1 is H, C1-4 alkyl or phenyl-(C1-4 alkyl), R2 is H or C1-4 alkyl and ring A is unsubstituted or halo- or hydroxy-substituted, as well as the physiologically-hydrolysable and -acceptable esters thereof have valuable pharmaceutical, in particular anti-inflammatory, antipyretic and analgesic properties.