98321-12-1

Upstream product

• 20433-19-6 5-phenyl-2-p-tolyl-2H-tetrazole 
• 49829-54-1 N-(p-tolyl)benzohydrazonoyl chloride 

Downstream Products

• 117600-96-1 1-((3aR,12bR)-3-Phenyl-1-p-tolyl-3a,12b-dihydro-1H-1,2,8-triaza-dibenzo[e,h]azulen-8-yl)-ethanone 
• 116857-90-0 1-(4-methylphenyl)-3-phenyl-4-acetylpyrazole 
• 116857-89-7 1-(4-methylphenyl)-3-phenyl-4,5-diacetylpyrazole 
• 117601-04-4 (3aR,12bR)-3-Phenyl-1-p-tolyl-3a,12b-dihydro-1H-1,2,8-triaza-dibenzo[e,h]azulene-8-carbonyl chloride 
• 117600-88-1 (3aR,12bR)-3-Phenyl-1-p-tolyl-1,3a,8,12b-tetrahydro-1,2,8-triaza-dibenzo[e,h]azulene 
• 117601-00-0 (3aR,12bR)-3-Phenyl-1-p-tolyl-3a,12b-dihydro-1H-1,2,8-triaza-dibenzo[e,h]azulene-8-carboxylic acid amide 

Relevant academic research and scientific papers

Regioselective synthetic approaches towards 1,2,8,9-tetraazadispiro[4.1.4.2]trideca-2,9-dien-6-ones of potential antimicrobial properties

Reaction of 2,5-bis(arylmethylidene)cyclopentanones 1a-d with nitrilimines (generated in situ via triethylamine dehydrohalogenation of the corresponding hydrazonoyl chlorides 2a,b) in 1:2 molar ratio proceeds in a high regioselective manner affording monocycloadducts 3 and dicycloadducts in the form of two isomers 4, 5. Single crystal X-ray diffraction studies of the isolated crystalline form of 3c support the established structure and indicate that the formed product is 7E, 4S, 5R. Antimicrobial activity screening of the synthesized compounds 3-5, utilizing a variety of Gram-positive (Staphylococcus aureus, Enterococcus fecalis and Streptococcus agalactiae), Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris) and yeast (Candida albicans), exhibited that all the prepared analogues acquire promising activities against both Gram-positive and Gram-negative bacteria especially compounds 3b, 4a (antimicrobial active agents against Gram-positive bacteria) and 3c (antimicrobial active agent against Gram-negative bacteria).

Photochemistry of Diarylsubstituted 2H-Tetrazoles, XI and Sydnones. V. Flashphotolytic Investigations with 2,5-Diaryl-2H-tetrazoles and 3,4-Diarylsydnones. Absolute Rate Constants of Cycloadditionreactions of Diarylnitrile Imines to Dipolarophils

The flash photolysis of 2,5-Diaryl-2H-tetrazoles 1 and 3,4-Diarylsydnones 2 was investigated.The nitrile imines were detected spectroscopically as short living intermediates.Rate constants of the cycloaddition reaction of nitrile imines and dipolarophiles

1,3-Dipolar Cycloadditions of Aryl Nitrilimines to Electron-poor Alkenes

The 1,3-dipolar cycloadditions of aryl nitrilimines to 1,2-diacetylethylene gave along with 1,2-diaryl-4,5-diacetyl-4,5-dihydropyrazoles 5 and the corresponding dehydrogenated pyrazoles 6, the unexpected 1,3-diaryl-4-acetylpyrazoles 7.As for tetrasubstituted alkenes, whereas 1,2-diacetyl-1,2-dicarbethoxyethylene gave a stable cycloadduct 8, 1,2,3,4-tetraacetylethylene yielded a mixture of pyrazoles 6 and 7.

Photochemistry of Diarylsubstituted 2H-Tetrazoles. II. The Influence of the Substituents on the Absorption Properties of Diarylsubstituted Nitrilimines

Irradation of 2,5-diaryl-2H-tetrazoles in an EPA-glass (ether: i-pentan: ethanol = 5:5:2) or in an i-pentan glass at 77-80 K with UV-light of wavelength 290 nm yields diarylnitrilimines by the extrusion of nitrogen.The photoreactions investigated show spe