98349-24-7

Basic information

• Product Name: Ethyl 2,4,5-trifluorobenzoylacetate
• Synonyms: 3-OXO-3-(2,4,5-TRIFLUORO-PHENYL)-PROPIONIC ACID ETHYL ESTER;ETHYL 3-(2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE;ETHYL 3-OXO-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE;ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE;2,4,5-Triflurobenzoflacetate;ETHYL 3-OXO-3(2,4,5-TRIFLUOROPHENYL) PROPIONATE;Ethyl (2,4,5-trifluorobenzoyl)acetate, Ethyl 2-(2,4,5-trifluorobenzoyl)ethanoate;ethyl 2,4,5-trifluorobenzoylacetat
• CAS NO: 98349-24-7
• Molecular Formula: C₁₁H₉F₃O₃
• Molecular Weight: 246.18
• Product Categories: Phenyls & Phenyl-Het;Benzoic acid;Phenyls & Phenyl-Het
• Mol File: 98349-24-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 66-68°C
• Boiling Point: 283.1 °C at 760 mmHg
• Flash Point: 121.2 °C
• Appearance: off-white crystall powder
• Density: 1.319 g/cm³
• Vapor Pressure: 0.00322mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Toluene
• PKA: 10.26±0.50(Predicted)
• CAS DataBase Reference: Ethyl 2,4,5-trifluorobenzoylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,4,5-trifluorobenzoylacetate(98349-24-7)
• EPA Substance Registry System: Ethyl 2,4,5-trifluorobenzoylacetate(98349-24-7)

Safety Data

• Hazard Codes: C,Xi,T
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: UN2811 6.1
• HazardClass: IRRITANT
• Hazardous Substances Data: 98349-24-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystall powder

Uses

Ethyl 2,4,5-Trifluoro-β-oxobenzenepropanoate can be used to prepare aminopyrrolidinyl)quinolinecarboxylates with antitumor activities.

InChI:InChI=1/C11H9F3O3/c1-2-17-11(16)5-10(15)6-3-8(13)9(14)4-7(6)12/h3-4H,2,5H2,1H3

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 104600-15-9 (2,4,5-trifluorobenzoyl)propanedioic acid, diethyl ester 
• 119209-55-1 propanedioic acid monoethyl ester dilithium salt 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 6148-64-7 ethyl potassium malonate 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 98349-22-5 2,4,5-trifluorobenzonitrile 
• 367-23-7 1,2,4-trifluorobenzene 
• 129322-83-4 2',4',5'-trifluoroacetophenone 
• 105-58-8 Diethyl carbonate 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 108115-65-7 (Z)-3-Phenylamino-2-(2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester 
• 108115-66-8 ethyl 3-(4-fuoroanilino)-2-(2,4,5-trifuorobenzoyl)acrylate 
• 154359-92-9 3,3-Bis-ethylsulfanyl-2-(2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester 
• 98349-25-8 ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 101799-76-2 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester 
• 129579-54-0 Ethyl 1-p-fluorophenyl-2-mercapto-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 129579-50-6 6,7-Difluoro-9-p-fluorophenyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione 
• 111279-75-5 Ethyl 1-p-fluorophenyl-2-methylthio-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 111279-87-9 6-Fluoro-7-piperazin-1-yl-9-cyclopropyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione 
• 111279-77-7 Ethyl 1-p-fluorophenyl-2-methylsulfinyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 129579-49-3 6-Fluoro-7-piperazin-1-yl-9-p-fluorophenyl-2,3,4,9-tetrahydroisothiazolo<5,4-b>quinoline-3,4-dione 
• 132920-58-2 ethyl 1-(1-diphenylmethylazetidin-3-yl)-6,7-difluoro-1,4-dihydro-4-oxoquinolin-3-carboxylate 

Relevant articles and documents

Refining method of ciprofloxacin and meglumine hydrochloride thereof

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Quinolone dimers as potential antibacterial agents

A series of novel 6-fluoro1,4-dihydro-4-oxo-3-quinoline carboxylic acid dimers (34-37), were synthesized as potential antibacterial agents from commercially available fluoro benzoic acids.

PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS

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