98369-58-5Relevant academic research and scientific papers
Chiral heterocyclic β-enamino esters: Convenient synthesis and diastereoselective reduction
Calvet, Sandrine,David, Olivier,Vanucci-Bacqué, Corinne,Fargeau-Bellassoued, Marie-Claude,Lhommet, Gérard
, p. 6333 - 6339 (2003)
The preparation of chiral pyrrolidine and piperidine β-enamino esters starting from ω-halogeno β-keto esters, their diastereoselective reduction and the subsequent cleavage of the chiral auxiliary are described.
C/O-Alkylation Ratios in the Ring-Closures of 7-Halo-3-oxo Esters
Brandaenge, Svante,Lindquist, Bo
, p. 807 - 810 (2007/10/02)
Four acyclic 7-halo-3-oxo esters have been treated with bases under various conditions to obtain six-membered ring compounds.These halo keto esters give more O-alkylation (C/O = 0.18-3.2) than do the analogous halo ketones.
