98491-27-1Relevant academic research and scientific papers
Wake-promoting agents: Search for next generation modafinil: Part i
Dunn, Derek,Hostetler, Greg,Iqbal, Mohamed,Messina-Mclaughlin, Patricia,Reiboldt, Alyssa,Lin, Yin Guo,Gruner, John,Bacon, Edward R.,Ator, Mark A.,Chatterjee, Sankar
scheme or table, p. 2312 - 2314 (2012/05/04)
In search of a next generation molecule to the novel wake promoting agent modafinil, a series of bi-phenyl derived wakefulness enhancing agents (in rat) was developed. From this work, compound 17 has been selected for additional studies.
Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: Effects of substitution of benzyl group in S-benzylisothiourea
Iwai, Noritaka,Fujii, Takuya,Nagura, Hirokatsu,Wachi, Masaaki,Kitazume, Tomoya
, p. 246 - 248 (2008/03/13)
We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl 2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.
