98545-68-7

Usage

Chemical structure

A benzene ring with a bromo, nitro, and two methoxy groups attached.

Classification

An organic compound.

Functional groups

Bromo, nitro, and methoxy groups.

Reactivity

The bromine atom makes the compound reactive and suitable for further chemical transformations.

Precursor

Useful precursor for the synthesis of pharmaceuticals and agrochemicals due to the presence of the nitro group.

Steric hindrance

The two methoxy groups add steric hindrance, which can influence the compound's reactivity and pharmacological properties.

Applications

Used in organic synthesis and pharmaceutical research as a building block for various compounds.

Versatility

A versatile chemical building block with potential applications in drug discovery and synthesis.

Molecular weight

Approximately 256.05 g/mol

Appearance

Yellow to light brown crystalline solid

Solubility

Soluble in organic solvents like dichloromethane, acetone, and ethanol, but less soluble in water.

Stability

Stable under normal temperature and pressure, but sensitive to heat, light, and moisture.

Hazards

Potential irritant and toxic if ingested, inhaled, or absorbed through the skin. Proper handling and storage are necessary to minimize risks.

Regulatory status

May be subject to specific regulations and restrictions depending on the intended use and location.

Upstream product

• 6313-37-7 2,5-dimethoxy-4-nitroaniline 
• 89-39-4 1,4-dimethoxy-2-nitrobenzene 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 31558-41-5 4-bromo-2,5-dimethoxybenzaldehyde 
• 35458-39-0 4-bromo-2,5-dimethoxybenzoic acid 
• 3467-59-2 2,5-dimethoxyacetanilide 
• 25445-13-0 2,5-dimethoxy-4-nitroacetanilide 

Downstream Products

• 14227-14-6 1,2,4-trimethoxy-5-nitrobenzene 
• 100960-04-1 4-methoxy-6-nitro-resorcinol 
• 56240-94-9 2,5-Dimethoxy-4-nitro-phenol 
• 4527-29-1 2-(2,5-Dimethoxy-4-nitro-phenylsulfanyl)-acetamide 
• 4527-54-2 (2,5-Dimethoxy-4-nitro-benzenesulfonyl)-acetic acid 
• 2989-87-9 2-(2,5-Dimethoxy-4-nitro-phenylsulfanyl)-N-hydroxy-acetamide 
• 4527-27-9 (2,5-Dimethoxy-4-nitro-phenylsulfanyl)-acetic acid methyl ester 
• 102871-30-7 5-ethoxy-4-methoxy-2-nitro-phenol 
• 7158-91-0 4,5-Dimethoxy-2-nitro-phenol 
• 4527-53-1 (2,5-Dimethoxy-4-nitro-phenylsulfanyl)-acetic acid 
• 151252-61-8 1-bromo-2,5-dihydroxy-4-nitrobenzene 

Relevant academic research and scientific papers

Electrochemical Nitration with Nitrite

Aromatic nitration has tremendous importance in organic chemistry as nitroaromatic compounds serve as versatile building blocks. This study represents the electrochemical aromatic nitration with NBu4NO2, which serves a dual role as supporting electrolyte and as a safe, readily available, and easy-to-handle nitro source. Stoichiometric amounts of 1,1,1-3,3,3-hexafluoroisopropan-2-ol (HFIP) in MeCN significantly increase the yield by solvent control. The reaction mechanism is based on electrochemical oxidation of nitrite to NO2, which initiates the nitration reaction in a divided electrolysis cell with inexpensive graphite electrodes. Overall, the reaction is demonstrated for 20 examples with yields of up to 88 %. Scalability is demonstrated by a 13-fold scale-up.

D superprecision molecular porous polymer, its monomer compound and preparation method (by machine translation)

The invention discloses a d superprecision molecular porous polymer, its monomer compound and its preparation method. The invention of d superprecision molecular porous polymer for use in the monomer molecule is introduced in the amphipathic group, throug

Red, far-red, and near infrared photoswitches based on azonium ions

Azonium ions formed by p-amino substituted azo compounds with both ortho- and meta-methoxy substituents exhibit strong absorbance in far-red and near infrared spectral region. The compounds undergo robust photoswitching in aqueous solution and exhibit a r

A convenient preparation of 7-bromo-2H-1,4-benzothiazine-3,5,8(4H)-trione and its application in the synthesis of the conaquinone B skeleton

7-Bromo-2H-1,4-benzothiazine-3,5,8(4H)-trione was synthesized by reaction of 5-bromo-2-nitro-1,4-benzoquinone with methyl thioglycolate followed by reductive cyclization and oxidation. The Diels-Alder reaction of the product quinone with myrcene afforded

Prodrug substituted benzoxazoles as estrogenic agents

This invention provides estrogen receptor modulators of formula I, having the structure wherein Q, Q2, R1, R2, R2a, R3, R3a, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.

Nitration of electron-rich aromatic compounds by cerium ammonium nitrate coated on silica

Treatment of electron-rich aromatic derivatives with cerium (IV) ammonium nitrate coated on silica (CANSio2) affords nitro aromatic compounds. The scope and the limitation of this reaction are discussed.

Nitrodecarboxylation and nitrodeformylation of some electron-rich benzoic acids and benzaldehydes

The nitration ipso to a carboxylic or formyl group of disubstituted and trisubstituted benzoic acids and benzaldehydes using nitric acid in acetic acid is described.