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Usage

Uses

Used in Pharmaceutical Research:
3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester is used as a building block for the synthesis of new drugs and biologically active compounds. Its unique structure and properties allow for the development of compounds with potential therapeutic applications, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Research:
In the agrochemical industry, 3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester serves as a key component in the synthesis of various biologically active compounds. Its versatility in chemical reactions enables the creation of new compounds with potential applications in agriculture, such as pesticides, herbicides, and other crop protection agents, thereby enhancing crop yield and quality.

Upstream product

• 75680-92-1 6-chloro-3-pyridazinecarboxylic acid ethyl ester 
• 98140-96-6 6-aminopyridazine-3-carboxylic acid methyl ester 
• 64-17-5 ethanol 

Downstream Products

• 1402608-81-4 ethyl 2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazine-6-carboxylate 

Relevant academic research and scientific papers

New tetrahydropyrido pyrimidinecarboxylic compound or salt thereof

To provide a compound having an inhibitory activity for an androgen receptor. A tetrahydropyridopyrimidine compound represented by the following general formula (I) or a pharmaceutically acceptable thereof (in the formula, X and R are as defined in the specification).

Highly efficient one-pot amination of carboxylate-substituted nitrogen-containing heteroaryl chlorides via Staudinger reaction

An efficient one-pot method for the synthesis of tert-butyl 6-aminonicotinate (5) is described. The key transformation involves displacement of the chloro group in tert-butyl 6-chloronicotinate (2) with azide followed by a Staudinger reaction. The scope of this methodology is further extended for the synthesis of a series of carboxylate-substituted heteroaryl amines. In particular, we synthesized tert-butyl carboxylate-substituted amino-pyridine, -pyridazine, and -pyrazine. In addition to one-pot conversion, short reaction time, simplicity of operation, ease of purification, and good yields are the key advantages of this methodology.