98550-70-0Relevant academic research and scientific papers
Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics
Stiff, Cory,Graber, David R.,Thorarensen, Atli,Wakefield, Brian D.,Marotti, Keith R.,Melchior, Earline P.,Sweeney, Michael T.,Han, Fusen,Rohrer, Douglas C.,Zurenko, Gary E.,Romero, Donna L.
scheme or table, p. 6293 - 6297 (2009/07/18)
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure-activity relationships of the indazol bioisosteres are described herein.
4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid derivatives
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, (2008/06/13)
4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acids and esters and alkali metal salts thereof, useful as anti-inflammatory, anti-allergic and anti-parasitic agents, are prepared by reacting a 4- or 5-R3 -2-carboxyphenylhydrazine with a lower-alkyl ethoxymethylenecyanoacetate and, if desired, saponifying the ester group and if desired, N-alkylating the product by reaction with an R2 -halide in the presence of an acid-acceptor.
