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98572-00-0

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98572-00-0 Usage

General Description

(S)-2-(Hydroxymethyl)-1,4-benzodioxane, also known as Safrole, is a colorless or slightly yellow oily liquid that is used primarily as a precursor in the synthesis of the recreational drug MDMA, also known as Ecstasy. It is naturally found in the sassafras plant and has a sweet, spicy aroma. Safrole is a potentially harmful chemical, as it has been shown to be carcinogenic and mutagenic in animal studies. Due to its toxic properties and its use in the illegal drug trade, the use and production of Safrole are heavily regulated in many countries. Despite its potential risks, Safrole has also been studied for its potential medicinal properties, including its antioxidant and antimicrobial effects.

Check Digit Verification of cas no

The CAS Registry Mumber 98572-00-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,5,7 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98572-00:
(7*9)+(6*8)+(5*5)+(4*7)+(3*2)+(2*0)+(1*0)=170
170 % 10 = 0
So 98572-00-0 is a valid CAS Registry Number.

98572-00-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name [(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methanol

1.2 Other means of identification

Product number -
Other names (S)-(-)-2-(hydroxymethyl)-1,4-benzodioxan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98572-00-0 SDS

98572-00-0Relevant articles and documents

Lipase-catalyzed kinetic resolution of (±)-2-hydroxymethyl-1,4-benzodioxane

Antus,Gottsegen,Kajtar,Kovacs,Toth,Wagner

, p. 339 - 344 (1993)

The title compound has been kinetically resolved in a lipase-catalyzed transesterification with vinyl acetae in organic solvents. The influence of the enzyme source as well as the character of the solvent on the enantioselectivity has been studied.

Method for synthesizing optically pure 2-hydroxymethyl-1,4-benzodioxin and derivatives of optically pure 2-hydroxymethyl-1,4-benzodioxin

-

Paragraph 0030-0032; 0034; 0035-0038, (2019/06/30)

The invention discloses a method for synthesizing optically pure 2-hydroxymethyl-1,4-benzodioxin and derivatives of the optically pure 2-hydroxymethyl-1,4-benzodioxin. The method comprises the steps that cheap 2-bromophenol or derivatives of the 2-bromoph

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles

Guo, Bin,Guo, Shimeng,Huang, Jing,Li, Jingya,Li, Jia,Chen, Qian,Zhou, Xianli,Xie, Xin,Yang, Yushe

, p. 5780 - 5791 (2018/11/06)

GPR40 has become a new potential therapeutic target for the treatment of diabetes due to its role in mediating the enhancement of glucose-stimulated insulin secretion in pancreatic β cells with a low risk of hypoglycemia. As an effort to extend the chemical space and identify structurally distinct GPR40 agonists with improved liver safety, a novel series of fused-ring phenyl propanoic acid analogues were designed. Comprehensive structure-activity relationship studies around novel scaffolds were conducted and led to several analogues exhibited potent GPR40 agonistic activities and high selectivity against other fatty acid receptors. Further evaluation of pharmacokinetic (PK) profiles and in vivo efficacy identified compound 40a with excellent PK properties and significant glucose-lowering efficacy during an oral glucose tolerance test. In addition, compound 40a displayed lower hepatobiliary transporter inhibition and favorable druggability. All results indicate that compound 40a is a promising candidate for further development.

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