98583-84-7

Upstream product

• 36685-63-9 (E)-2,4-dimethoxy-2'-hydroxychalcone 
• 118-93-4 o-hydroxyacetophenone 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 63487-16-1 2-(2,4-dimethoxyphenyl)-4H-chromen-4-one 
• 742096-88-4 2-(5-chloro-2,4-dimethoxy-phenyl)-chromen-4-one 
• 170310-00-6 2’,4’-dihydroxyflavone 

Relevant academic research and scientific papers

Aspergillus niger catalyzes the synthesis of flavonoids from chalcones

Flavonoids, which have many biological activities and have been widely used in nature, can be artificially synthesized. However, regioselective cyclization of chalcones is difficult by chemical methods. In this study, we demonstrated that Aspergillus nige

Glycolytic inhibition and antidiabetic activity on synthesized flavanone scaffolds with computer aided drug designing tools

Background: Diabetes mellitus is a challengeable metabolic disorder that leads to a group of complications when the HbA1c level is not maintained. Most of the existing drugs avail-able in the market in long-term use may lead to serious adverse effects. He

Synthesis and kinetic investigations for the isomerization process of 2–hydroxy chalcone derivatives

The wide biological activities of flavanones are mainly depends on their physical and chemical properties, thus a number of substituted 2-Hydroxy chalcones have been synthesized, and their isomerization to their corresponding flavanones was studied. In order to determine the rate constant, kinetic experiments were performed using HPLC technique in (9:1) (CH3CN:H2O) medium at different temperature (298-318) K. The obtained results were interpreted by four steps mechanism, which considered the existence of phenoxide ion as the key intermediate. This study performed with a pseudo first order (reaction in which the rate for the studied compounds follow the sequence 5 > 2 > 1 > 4 > 3, the activation energy have the same sequence for these compounds .The effect of substituents on the rate showed that electronic and steric factors play reasonable role on the stability of the product .

Cyclodehydrogenation of 2'-Hydroxychalcones with DDQ: A Simple Route for Flavones and Aurones

The oxidation of 2'-hydroxychalcones with 2,3-dichloro-5,6-dicyano-p-benzoquinone provides a useful synthetic route for flavones and aurones.

Photochemical Cyclization of 2'-Hydroxychalcones

A series of 4-substituted 2'-hydroxychalcones underwent photocyclization to give the corresponding flavones selectively, but in low quantum yields, on visible irradiation in polar aprotic solvents.Hydroxylic solvents, which disturbed the formation of a cyclic intramolecular hydrogen bond, strongly retarded the photoreaction, while neither triplet quenchers nor free radical inhibitors affected the reaction.The quantum yields were independent of the light intensity, implying a one-photon process, but strongly depended on the wavelength of irradiation.Mechanisms were proposed assuming ?, ?* excited states and Weller's postulate of a dynamic equilibrium in a proton-transfer double-minimum potential.