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5'-Des-O-methylhomoharringtonine is a metabolite of Homoharringtonine, a cytotoxic component derived from the evergreen plant Cephalotaxus harringtonia. It possesses significant biological activity and has been extensively studied for its potential therapeutic applications.

98599-84-9

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98599-84-9 Usage

Uses

Used in Pharmaceutical Industry:
5'-Des-O-methylhomoharringtonine is used as an anticancer agent for its ability to inhibit the growth and proliferation of cancer cells. It is particularly effective against various types of leukemia and has been incorporated into combination chemotherapy regimens to enhance treatment outcomes.
Additionally, 5'-Des-O-methylhomoharringtonine is used as an immunosuppressive agent in the treatment of autoimmune diseases and transplantation medicine. Its immunosuppressive properties help to prevent organ rejection and manage inflammatory conditions.
In the field of drug development, 5'-Des-O-methylhomoharringtonine serves as a valuable template for the synthesis of novel compounds with improved pharmacological properties. Researchers are actively exploring its potential for the development of new drugs with enhanced efficacy and reduced side effects.
Furthermore, 5'-Des-O-methylhomoharringtonine is used in the study of molecular mechanisms underlying cancer cell growth and apoptosis. Understanding its mode of action can provide insights into the development of targeted therapies and personalized medicine approaches.
Overall, 5'-Des-O-methylhomoharringtonine is a promising compound with diverse applications in the pharmaceutical industry, ranging from cancer treatment to drug development and research. Its unique properties and potential for further exploration make it an important area of focus for scientists and healthcare professionals alike.

Check Digit Verification of cas no

The CAS Registry Mumber 98599-84-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,5,9 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 98599-84:
(7*9)+(6*8)+(5*5)+(4*9)+(3*9)+(2*8)+(1*4)=219
219 % 10 = 9
So 98599-84-9 is a valid CAS Registry Number.

98599-84-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Cephalotaxine 4-Hydrogen (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)

1.2 Other means of identification

Product number -
Other names 4'-Demethyl Homoharringtonine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98599-84-9 SDS

98599-84-9Upstream product

98599-84-9Downstream Products

98599-84-9Relevant academic research and scientific papers

AMINATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

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Paragraph 0072; 0073; 0075; 0076, (2014/07/08)

The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

AMINATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

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Paragraph 0088; 0089, (2014/08/06)

The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

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