98612-84-1Relevant academic research and scientific papers
Synthetic Transformation of Santonin into (5α,7α,11β)-3,6-Dioxogermacr-1-en-13,7-olide, a New Intermediate for Germacranes and Guaianes
Harapanhalli, Ravi S.
, p. 1009 - 1012 (2007/10/02)
A seven-step synthesis of a new intermediate (5α,7α,11β)-3,6-dioxogermacr-1-en-13,7-olide (10) is described starting from (-)-α-santonin (1).The key step in the transformation was photolytic skeletal rearrangement of (4α,5β,6α,11β)-5-hydroxy-2-oxoeudesman-13,6-olide (9) to the title compound, sensitised by mercuric oxide and iodine.
