98626-66-5Relevant academic research and scientific papers
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: Design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists
Wu, Wen-Lian,Burnett, Duane A.,Spring, Richard,Greenlee, William J.,Smith, Michelle,Favreau, Leonard,Fawzi, Ahmad,Zhang, Hongtao,Lachowicz, Jean E.
, p. 680 - 693 (2007/10/03)
Benzazepines 1 and 2 (SCH 23390 and SCH 39166, respectively) are two classical benzazepine D1/D5 antagonists, with K i values 1.4 and 1.2 nM, respectively. Compound 2 has been in human clinical trials for a variety of dise
SELECTIVE D1/D5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND CNS DISORDERS
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Page 37, (2010/02/06)
The present invention provides compounds, which, are novel antagonists for D1/D5 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1/D5 receptor antagonist
