98627-70-4

Basic information

• Product Name: Bis-(Aminoxy)-PEG3
• Synonyms: Bis-(Aminoxy)-PEG3;Bis-(Aminooxy)-PEG3;Aminoxy-PEG3-Aminoxy
• CAS NO: 98627-70-4
• Molecular Formula: C8H20N2O5
• Molecular Weight: 224.2548
• Mol File: 98627-70-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Soluble in DCM,H2O, DMF, DMSO
• CAS DataBase Reference: Bis-(Aminoxy)-PEG3(CAS DataBase Reference)
• NIST Chemistry Reference: Bis-(Aminoxy)-PEG3(98627-70-4)
• EPA Substance Registry System: Bis-(Aminoxy)-PEG3(98627-70-4)

Safety Data

• Hazardous Substances Data: 98627-70-4(Hazardous Substances Data)

Usage

Description

Bis-aminooxy-PEG3 is an water soluble crosslinker containing two aminooxy groups. Aminooxy (ONH2) group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond or a hydroxylamine linkage under reduction condition Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

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Relevant articles and documents

THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME

The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.

BLOOD COAGULATION PROTEIN CONJUGATES

The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer. In one embodiment of the invention the conjugation is carried out in the presence of the nucleophilic catalyst aniline. In addition the generated oxime linkage can be stabilized by reduction with NaCNBH3 to form an alkoxyamine linkage.

PHENAZINE AND QUINOXALINE SUBSTITUTED AMINO ACIDS AND POLYPEPTIDES

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a phenazine or quinoxaline substituent. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides.