98632-99-6

Basic information

• Product Name: N-ACETYL-5-METHOXY SERINE
• Synonyms: N-ACETYL-5-METHOXY SERINE;N-Acetyl-O-methyl-serine;2-ACETAMIDO-3-METHOXYPROPANOIC ACID
• CAS NO: 98632-99-6
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.16
• Mol File: 98632-99-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 393.4 °C at 760 mmHg
• Flash Point: 191.7 °C
• Appearance: /
• Density: 1.194
• Vapor Pressure: 2.76E-07mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: N-ACETYL-5-METHOXY SERINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-5-METHOXY SERINE(98632-99-6)
• EPA Substance Registry System: N-ACETYL-5-METHOXY SERINE(98632-99-6)

Safety Data

• Hazardous Substances Data: 98632-99-6(Hazardous Substances Data)

Usage

General Description

N-Acetyl-5-methoxy serine is a chemical compound that is derived from the amino acid serine. It contains an acetyl group and a methoxy group, both of which are attached to the fifth carbon of the serine molecule. This chemical compound has been studied for its potential therapeutic properties, specifically in the treatment of neurological disorders and cognitive impairment. It is believed to have neuroprotective and antioxidant effects, which could make it a promising candidate for treating conditions such as Alzheimer's disease and age-related cognitive decline. Furthermore, N-Acetyl-5-methoxy serine may also have potential applications in improving memory and cognitive function in healthy individuals. However, further research is needed to fully understand its mechanisms of action and potential medical uses.

InChI:InChI=1/C6H11NO4/c1-4(8)7-5(3-11-2)6(9)10/h5H,3H2,1-2H3,(H,7,8)(H,9,10)

Upstream product

• 19794-53-7 3-methoxy-2-aminopropionic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 19794-53-7 3-methoxy-2-aminopropionic acid 
• 1206635-00-8 (R)-N-4-(sulfamoyl)benzyl 2-acetamido-3-methoxypropionamide 
• 4219-94-7 DL-3-methoxy-alanine 
• 196601-67-9 (R)-2-N-acetamido-3-methoxypropionic acid 
• 175481-26-2 2-acetamido-N-benzyl-3-methoxypropionamide 

Relevant articles and documents

PROCESS FOR PREPARING LACOSAMIDE

The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.

Synthesis and anticonvulsant activities of (R)-N-(4′-substituted) benzyl 2-acetamido-3-methoxypropionamides

The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent (R)-lacosamide [(R)-N-benzyl 2-acetamido-3- methoxypropionamide, (R)-3] has been explored. Forty-three compounds were prepared and then evaluated at the National Institute of Neurological Disorders and Stroke Anticonvulsant Screening Program for seizure protection in the maximal electroshock (MES) and subcutaneous Metrazol models. Comparing activities for two series of substituted aryl regioisomers (2′, 3′, 4′) showed that 4′-modified derivatives had the highest activity. Significantly, structural latitude existed at the 4′-site. The SAR indicated that nonbulky 4′-substituted (R)-3 derivatives exhibited superb activity, independent of their electronic properties. Activities in the MES test of several compounds were comparable with or exceeded that of (R)-3 and surpassed the activities observed for the traditional antiepileptic agents phenytoin, phenobarbital, and valproate. 2009 American Chemical Society.