98634-97-0

Basic information

• Product Name: Ai3-05827
• Synonyms: Ai3-05827
• CAS NO: 98634-97-0
• Molecular Formula: C6H8O3
• Molecular Weight: 128.12592
• Mol File: 98634-97-0.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ai3-05827(CAS DataBase Reference)
• NIST Chemistry Reference: Ai3-05827(98634-97-0)
• EPA Substance Registry System: Ai3-05827(98634-97-0)

Safety Data

• Hazardous Substances Data: 98634-97-0(Hazardous Substances Data)

Upstream product

• 75-21-8 oxirane 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 2280-44-6 D-Glucose 
• 96-48-0 4-butanolide 
• 141-78-6 ethyl acetate 
• 7647-01-0 hydrogenchloride 
• 412012-07-8 2-acetyl-2-(methylsulfanyl-methyl)-succinic acid diethyl ester 
• 75-07-0 acetaldehyde 
• 79-20-9 acetic acid methyl ester 
• 108-24-7 acetic anhydride 
• 1258864-02-6 C₁₉H₂₀ClNO₄ 
• 64620-59-3 3-<1-(N-phenylamino)-ethylidene>-4,5-dihydro-2(3H)-furanone 

Downstream Products

• 64745-38-6 3-[1-(2,5-dichloro-phenylimino)-ethyl]-dihydro-furan-2-one 
• 740845-82-3 4-(2-hydroxy-ethyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 64745-43-3 3-[1-(2-methoxy-phenylimino)-ethyl]-dihydro-furan-2-one 
• 64745-28-4 3-(1-p-tolylimino-ethyl)-dihydro-furan-2-one 
• 64745-37-5 3-[1-(4-chloro-phenylimino)-ethyl]-dihydro-furan-2-one 
• 91093-05-9 3-(4-nitro-benzoyl)-dihydro-furan-2-one 
• 64745-26-2 3-(1-phenylimino-ethyl)-dihydro-furan-2-one 
• 64745-32-0 3-[1-(2-hydroxy-phenylimino)-ethyl]-dihydro-furan-2-one 
• 100518-24-9 3-[1-(2,4-dinitro-phenylhydrazono)-ethyl]-dihydro-furan-2-one 
• 64745-33-1 3-[1-(3-hydroxy-phenylimino)-ethyl]-dihydro-furan-2-one 
• 64745-45-5 3-[1-(3-nitro-phenylimino)-ethyl]-dihydro-furan-2-one 
• 64745-27-3 3-(1-o-tolylimino-ethyl)-dihydro-furan-2-one 

Relevant articles and documents

Application of liquid sodium methoxide in synthesis of alpha-acetyl-gamma-butyrolactone and synthesis method of alpha-acetyl-gamma-butyrolactone

The invention provides application of liquid sodium methoxide in synthesis of alpha-acetyl-gamma-butyrolactone and a synthesis method of the alpha-acetyl-gamma-butyrolactone, and relates to the technical field of organic synthesis. The synthesis method of the alpha-acetyl-gamma-butyrolactone comprises the following steps: (a) performing pre-acylation reaction on an acetate compound and gamma-butyrolactone; (b) adding liquid sodium methoxide into the reaction liquid in the step (a) to carry out mixed reaction; (c) after the reaction in the step (b) is finished, concentrating and collecting methanol, and transferring the concentrated reaction liquid into an acylation kettle; (d) supplementing the acetate compound into the acylation kettle for acylation reaction; (e) performing neutralizing, filtering and concentrating to obtain an alpha-acetyl-gamma-butyrolactone crude product. According to the method, liquid sodium methoxide is used for replacing solid sodium methoxide for acylation synthesis, so that liquification and sealing of feeding are realized, the on-site feeding risk is reduced, and the synthesis yield is increased to 96% or above.

Process for dissociating acetamidine hydrochloride with alpha-acetyl-gamma-butyrolactone sodium salt

The invention relates to the technical field of vitamin B synthesis intermediates, in particular to a process for dissociating acetamidine hydrochloride with alpha-acetyl-gamma-butyrolactone sodium salt. The process comprises the following steps: making alpha-acetyl-gamma-butyrolactone sodium salt react with the acetamidine hydrochloride and separating products to obtain acetamidine and alpha-acetyl-gamma-butyrolactone. According to the process, the intermediate product alpha-acetyl-gamma-butyrolactone sodium salt in the synthesis step of the alpha-acetyl-gamma-butyrolactone reacts with the acetamidine hydrochloride, the alpha-acetyl-gamma-butyrolactone sodium salt utilize hydrochloric acid coordinated in the acetamidine hydrochloride to achieve the effect that the alpha-acetyl-gamma-butyrolactone sodium salt produces the alpha-acetyl-gamma-butyrolactone, and the hydrochloric acid in the acetamidine hydrochloride is removed to form acetamidine. Synchronous production of two target products is achieved, the steps are saved, and the process is environmentally friendly and increases the revenue.

Method for preparing alpha-acetyl-gamma-butyrolactone

The invention discloses a method for preparing alpha-acetyl-gamma-butyrolactone. The method comprises the following steps: adding ethyl acetate and sodium carbonate into a three-necked flask, dropwiseadding gamma-butyrolactone at the temperature of 44 to 46 DEG C, stirring, mixing the ethyl acetate and liquid aldehyde, dropwise adding a reaction solution, uniformly mixing, stirring and reacting for 1.5 to 2.5 hours at the temperature of 54 to 58 DEG C, adding the reaction solution into a high-pressure kettle, reacting for 5 to 6 hours at the temperature of 80 to 85 DEG C, cooling to room temperature, adding the reaction solution into a three-necked flask, dropwise adding sulfuric acid at 3 to 5 DEG C to adjust the pH to be 6 to 7, precipitating solids in the dropwise addition process, after the addition is ended, stirring for 11 to 13 hours, re-testing the pH which is unchanged, filtering to remove the solids, washing a filter cake by using ethyl acetate, performing the decompressionrotary evaporation, removing the ethyl acetate until no fraction is outputted, obtaining a crude product, and performing the direct decompression rectification for the crude product. The preparation method is easy in obtaining raw materials, cheap in raw materials, easy in operation, higher in yield, and suitable for industrialized production.