98642-16-1Relevant articles and documents
Guanosine-specific DNA damage by a Co(II)·bithiazole complex
Kane,Sasaki,Hecht
, p. 9107 - 9118 (1995)
A bithiazole derivative structurally related to the bithiazole moiety of bleomycin (BLM) A2 was prepared. This derivative contained a 2-(1,3-diaminopropyl) substituent, rather than the 2-(2-aminoethyl) substituent normally present in BLM, in or
Acylated aminopropanediols and analogues and therapeutic uses thereof
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Page/Page column 24, (2008/06/13)
The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method of preparing said derivatives.
Therapeutic use of acyl glycerols and the nitrogen- and sulphur- containing analogues thereof
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Page/Page column 40, (2008/06/13)
The invention relates to the use of acyl glycerols and the nitrogen- and sulfur-containing analogues thereof in the therapeutic field, particularly in human health. The inventive compounds have advantageous pharmacological properties and are particularly of use for the prevention or treatment of neurodegenerative diseases.
Uses of acylated aminopropanediols and sulphur and nitrogen analogues of same f
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Page/Page column 26-27, (2008/06/13)
The invention relates to the use of molecules, particularly in the fields of human and veterinary health and cosmetics. The inventive compounds are acylated aminopropanediols and the nitrogen- and sulfur-containing analogues thereof and have advantageous pharmacological and cosmetic properties. In particular, the inventive compounds can be used to prevent and/or treat dyslipidemias, cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, some cancers, dermatological diseases, and, in the field of cosmetics, to combat skin ageing and the effects of same, in particular the development of wrinkles and the like.
Platinum(II) Complexes with Porphyrin Ligands: Synthesis and Synergisms in the Photodynamic Tumor Therapy
Brunner, Henri,Obermeier, Herbert,Szeimies, Rolf-Markus
, p. 173 - 182 (2007/10/02)
Twelve porphyrin ligands (2-5, 8, 13-16, 19, 27, 28) and their platinum(II) complexes (29-40) were synthesized and characterized.Nine of the porphyrins are derived from hemin, and three are based on tetraphenylporphyrin.The ligands were transformed into diamine-dicarboxylatoplatinum(II) complexes and diamine-dichloroplatinum(II) complexes.The antitumor activity in the photodynamic therapy of the ligands and their complexes was tested in vitro towards the MDA-MB-231 mammary carcinoma cell line.The results obtained showed an additive effect of the photodynamic activity of the porphyrin skeleton when irradiated with visible red light and the cytotoxic activity of the platinum moiety in the complexes. - Key Words: Porphyrins/ Platinum(II) complexes/ Photodynamic therapy/ Antitumor activity
Cyclic amidinyl and cyclic guanidinyl thio carbapenems
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, (2008/06/13)
Compounds of the formula: STR1 and the pharmaceutically acceptable salts thereof wherein X is STR2 wherein each R is hydrogen or alkyl of 1 to 6 carbon atoms are disclosed. The compounds are useful as antibiotics.