98655-51-7Relevant academic research and scientific papers
Copper/P(tBu)3-Mediated Regiospecific Synthesis of Fused Furans and Naphthofurans
Naveen, Togati,Deb, Arghya,Maiti, Debabrata
supporting information, p. 1111 - 1115 (2017/01/18)
A novel [3+2] cycloaddition between a variety of cyclic ketones and diverse olefins or alkynes can be effectively promoted by copper in combination with the tri-tert-butylphosphine [P(tBu)3] ligand. This protocol exhibits excellent selectivity and provides an exemplary set of fused heterocycles in good to excellent yields. Present strategy also represents an extremely simple and atom-economic way to construct substituted fused furans and naphthofurans from readily available starting materials under mild reaction conditions. The utility of the method is further demonstrated by the synthesis of chiral furans from (R)-(?)-carvone and (S)-(+)-carvone. A plausible mechanism involving the oxidative radical cyclization has been suggested based on experimental observations.
An efficient method to synthesize benzofurans and naphthofurans
Pan, Chongfeng,Yu, Jie,Zhou, Yuqing,Wang, Zhiyong,Zhou, Ming-Ming
, p. 1657 - 1662 (2008/02/04)
A new method for synthesis of benzofurans and naphthofurans from 2-hydroxystilbene derivatives via an intermolecular cyclization is reported in this study with up to 94% isolated yield. Georg Thieme Verlag Stuttgart.
New synthesis of 2-aryl-3-substituted benzo[b]furans from benzyl 2-halophenyl ethers
Sanz, Roberto,Miguel, Delia,Martinez, Alberto,Perez, Antonio
, p. 4024 - 4027 (2007/10/03)
Treatment of benzyl 2-halophenyl ethers with 3 equiv of t-BuLi results in Li-halogen exchange and lithiation at benzylic methylene simultaneously. These dianions do not undergo Wittig rearrangement and can be trapped with electrophiles. Their reactions with carboxylic esters afford the corresponding 2-aryl-3-hydroxy-2,3-dihydrobenzo[b]-furans as a mixture of diastereoisomers. Subsequent acid-catalyzed or mediated dehydration gives moderate to good overall yield of a variety of 2-aryl-3-substituted benzo[fe]-furans.
