98667-27-7Relevant academic research and scientific papers
Tetrahydro-β-carboline derivatives and treatment of liver diseases
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, (2008/06/13)
Novel tetrahydro-β-carboline derivatives of the formula: STR1 wherein R1 is carboxyl, a lower alkoxycarbonyl, carbamoyl, an N,N-di-lower alkylcarbamoyl, an N-(phenyl-substituted lower alkylidenamino)carbamoyl, a [N,N-di(lower alkyl)amino]-lower alkyl, or a nitrogen-containing monocyclic heterocyclic group; R2 is hydrogen atom, a lower alkyl, or a hydroxy-lower alkyl group, or R2 is combined with R1 to form a group: --CO--O--CH2 --; R3 is hydrogen atom, a lower alkyl, a phenyl-lower alkyl, or a group: --CSS--R4 ; R4 is hydrogen atom, an alkyl, or a group: --(CH2)n Y1 ; n is 0, 1 or 2, Y1 is a lower alkenyl, a phenyl-substituted lower alkenyl, an N,N-di(lower alkyl)amino, a lower alkylmercapto, a lower alkoxycarbonyl, benzoyl, naphthyl, a cycloalkyl, a monocyclic heterocyclic group, or a substituted or unsubstituted phenyl, which have excellent activities for alleviating, curing and preventing hepatic damages and are useful as a therapeutic or prophylactic agent for hepatic diseases, and processes for the preparation thereof, and a pharmaceutical composition containing the above compound as an active ingredient.
