98669-82-0Relevant academic research and scientific papers
Cu1.5PMo12O40-catalyzed condensation cyclization for the synthesis of substituted pyrazoles
Yang, Guo-Ping,He, Xing,Yu, Bing,Hu, Chang-Wen
, (2018)
A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3-diketones in the presence of Cu1.5PMo12O40 (0.33?mol%) under mild conditions (r.t.-60?°C, 10–30?min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5-mmol scale. This solvent-free and halogen-free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles.
